What is TobraDex and how is it used?Tobradex is a prescription medicine used to treat the symptoms of Ocular Inflammation and Bacterial Infection of the eye. Tobradex may be used alone or with other medications. Show
Tobradex belongs to a class of drugs called Antibiotics/Corticosteroids, Opthalmic. It is not known if Tobradex is safe and effective in children younger than 2 years of age. What are the possible side effects of TobraDex?TobraDex may cause serious side effects including:
Get medical help right away, if you have any of the symptoms listed above. The most common side effects of Tobradex include:
Tell the doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of TobraDex. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. DESCRIPTIONTOBRADEX® (tobramycin and dexamethasone ophthalmic suspension) is a sterile, multiple dose antibiotic and steroid combination for topical ophthalmic use. The chemical structures for tobramycin and dexamethasone are presented below: TobramycinEmpirical Formula: C18H37N5O9 Chemical Name: O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[2,6-diamino-2,3,6-trideoxy-α- D-ribo-hexopyranosyl-(1→6)]-2-deoxy-L-streptamine DexamethasoneEmpirical Formula: C22H29FO5 Chemical Name: 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione Each mL of TOBRADEX® (tobramycin and dexamethasone ophthalmic suspension) contains: Actives: tobramycin 0.3% (3 mg) and dexamethasone 0.1% (1 mg). Preservative: benzalkonium chloride 0.01%. Inactives: tyloxapol, edetate disodium, sodium chloride, hydroxyethyl cellulose, sodium sulfate, sulfuric acid and/or sodium hydroxide (to adjust pH) and purified water. 3 pharmacies near 90245 have coupons for Tobradex (Brand Names:Tobradex for 5ML of 0.3-0.1%)Rite Aid Pharmacy $215.99 Est. Regular Price View Coupon INDICATIONSTOBREX® (tobramycin ophthalmic solution) 0.3% is a topical antibiotic indicated in the treatment of external infections of the eye and its adnexa caused by susceptible bacteria. Appropriate monitoring of bacterial response to topical antibiotic therapy should accompany the use of TOBREX. Clinical studies have shown tobramycin to be safe and effective for use in children. DOSAGE AND ADMINISTRATIONIn mild to moderate disease, instill 1 or 2 drops into the affected eye(s) every 4 hours. In severe infections, instill 2 drops into the eye(s) hourly until improvement, following which treatment should be reduced prior to discontinuation. HOW SUPPLIEDTOBREX (tobramycin ophthalmic solution) 0.3% is supplied as a 5 mL sterile solution, packaged in a 8 mL low density polyethylene white bottle and natural dispensing plug and white polypropylene closure as follows: 5 mL containing tobramycin 0.3% (3 mg/mL) - NDC 0065-0643-05 Storage: Store at 2°C to 25°C (36°F to 77°F). After opening, TOBREX (tobramycin ophthalmic solution) 0.3% can be used until the expiration date on the bottle. Distributed by: Novartis Pharmaceuticals Corporation East Hanover, New Jersey 07936. Revised: May 2021 QUESTIONWhat causes dry eyes? See AnswerSide Effects & Drug Interactions SIDE EFFECTSThe most frequent adverse reactions to TOBREX (tobramycin ophthalmic solution) 0.3% are hypersensitivity and localized ocular toxicity, including lid itching and swelling, and conjunctival erythema. These reactions occur in less than three of 100 patients treated with TOBREX®. Postmarketing ExperienceAdditional adverse reactions identified from post-marketing use include anaphylactic reaction, Stevens-Johnson syndrome, and erythema multiforme. The following additional adverse reactions have been reported with systemic aminoglycosides: Neurotoxicity, ototoxicity and nephrotoxicity have occurred in patients receiving systemic aminoglycoside therapy. Aminoglycosides may aggravate muscle weakness in patients with known or suspected neuromuscular disorders, such as myasthenia gravis or Parkinson’s disease, because of their potential effect on neuromuscular function. DRUG INTERACTIONSNo Information Provided WARNINGSFOR TOPICAL OPHTHALMIC USE. NOT FOR INJECTION INTO THE EYE. Sensitivity to topically applied aminoglycosides may occur in some patients. Severity of hypersensitivity reactions may vary from local effects to generalized reactions such as erythema, itching, urticaria, skin rash, anaphylaxis, anaphylactoid reactions, or bullous reactions. If a sensitivity reaction to TOBREX® (tobramycin ophthalmic solution) 0.3% occurs, discontinue use. PRECAUTIONSGeneralAs with other antibiotic preparations, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated. Cross-sensitivity to other aminoglycoside antibiotics may occur; if hypersensitivity develops with this product, discontinue use and institute appropriate therapy. Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial ocular infection. PregnancyReproduction studies in 3 types of animals at doses up to 33 times the normal human systemic dose have revealed no evidence of impaired fertility or harm to the fetus due to tobramycin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Nursing MothersBecause of the potential for adverse reactions in nursing infants from TOBREX, a decision should be made whether to discontinue nursing the infant or discontinue the drug, taking into account the importance of the drug to the mother. Pediatric UseSafety and effectiveness in pediatric patients below the age of 2 months has not been established. Geriatric UseNo overall differences in safety or effectiveness have been observed between elderly and younger patients. Overdose & Contraindications OVERDOSENo Information Provided CONTRAINDICATIONSTOBREX (tobramycin ophthalmic solution) 0.3% is contraindicated in patients with known hypersensitivity to any of its components. CLINICAL PHARMACOLOGYIn Vitro DataIn vitro studies have demonstrated tobramycin is active against susceptible strains of the following microorganisms: Staphylococci, including S. aureus and S. epidermidis (coagulase-positive and coagulase-negative), including penicillin-resistant strains. Streptococci, including some of the Group A-beta-hemolytic species, some nonhemolytic species, and some Streptococcus pneumoniae. Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris strains, Haemophilus influenzae and H. aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus and some Neisseria species. Bacterial susceptibility studies demonstrate that in some cases, microorganisms resistant to gentamicin retain susceptibility to tobramycin. PATIENT INFORMATIONDo not touch dropper tip to any surface, as this may contaminate the solution. FromReport Problems to the Food and Drug AdministrationYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088. How many days should I use tobramycin eye drops?Use the drops twice a day for seven days, unless you have been told otherwise by your doctor. Your vision may become slightly blurred for a short while after using the drops.
How often do you use tobramycin and dexamethasone ophthalmic suspension?Adults—Use 1 or 2 drops in the eye every four to six hours. Your doctor may have you use the drops more frequently during the first day or two and will probably have you space the doses farther apart as the eye gets better. Children—Use and dose must be determined by your doctor.
How long should dexamethasone eye drops be used?Dexamethasone eye drops are only meant to be used for a short period of time. Do not use them for longer than one week unless your doctor advises you otherwise. This is because they can cause problems within your eye when used for longer than recommended.
How long does it take for tobramycin ophthalmic to work?This medication should start having effects within 1 to 2 hours; however, you may not see the effects of this medication outwardly.
|