Which action would be the priority when implementing the treatment plan for a patient with DKA?

1. Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care 2009;32(7):1335–1343. [PMC free article] [PubMed] [Google Scholar]

2. Centers for Disease Control and Prevention. Mortality due to Hyperglycemic crises http://www.cdc.gov/diabetes/statistics/complications_national.htm. 11/19/2013. Accessed on 9/2/2016.

3. Ennis ED, Stahl EJVB, Kreisberg RA. The hyperosmolar hyperglycemic syndrome. Diabetes Rev 1994;2:115–126. [Google Scholar]

4. Umpierrez GE, Kelly JP, Navarrete JE, Casals MM, Kitabchi AE. Hyperglycemic crises in urban blacks. Arch Intern Med 1997;157(6):669–675. [PubMed] [Google Scholar]

5. von Stosch A Versuch einer Pathologie und Therapie des Diabetes Mellitus. Berlin, Duncker und Humblot, 1828. [in German].

6. Parsons J Case of Infantile Diabetes. Prov Med Surg J 1849;13(13):342–343. [PMC free article] [PubMed] [Google Scholar]

7. Hindle R Case of Acute Diabetes. Prov Med Surg J 1845;9(29):452–453. [PMC free article] [PubMed] [Google Scholar]

8. Favell CF. Cases of Diabetes. Prov Med J Retrosp Med Sci 1843;6(153):467–469. [PMC free article] [PubMed] [Google Scholar]

9. Kussmaul A Zur lehre vom diabetes mellitus. Dtsch Arch Klin Med 1874;14:1–46 [in German]. [Google Scholar]

10. Kussmaul Adolf (1822–1902)--Country Doctor to Clinical Professor. JAMA 1964;189:58–59. [PubMed] [Google Scholar]

11. Stadelmann E Ueber die Ursachen der pathologischen ammoniakausscheidung beim diabetes mellitus und des coma diabeticum. Arch Exp Pathol und Pharmakol 1883;17:419–444 [in German]. [Google Scholar]

12. Külz E Ueber eine neue linksdrehende saure (pseudo-oxybuttersaure). Zeitschr f Biologie 1884;20:165–178 [in German]. [Google Scholar]

13. Dreschfeld J The Bradshawe Lecture on Diabetic Coma. Br Med J 1886;2(1338):358–363. [PMC free article] [PubMed] [Google Scholar]

14. Banting FG, Best CH, Collip JB, Campbell WR, Fletcher AA. Pancreatic Extracts in the Treatment of Diabetes Mellitus: Preliminary Report. Can Med Assoc J 1962;87(20):1062–1067. [PMC free article] [PubMed] [Google Scholar]

15. Rabinowitch IM. Diabetic Coma and Diabetic Mortality Rates. Can Med Assoc J 1929;21(5):583–586. [PMC free article] [PubMed] [Google Scholar]

16. Clements RS Jr., Vourganti B. Fatal diabetic ketoacidosis: major causes and approaches to their prevention. Diabetes Care 1978;1(5):314–325. [PubMed] [Google Scholar]

17. Felig P Diabetic ketoacidosis. N Engl J Med 1974;290(24):1360–1363. [PubMed] [Google Scholar]

18. Graves EJ, Gillium BS. Detailed diagnosis and procedures: National Discharge Survey, 1995. National Center for Health Statistics. Vital Health Stat 1997;13((no. 133)). [Google Scholar]

19. Wagner A, Risse A, Brill HL, et al. Therapy of severe diabetic ketoacidosis. Zero-mortality under very-low-dose insulin application. Diabetes Care 1999;22(5):674–677. [PubMed] [Google Scholar]

20. Pasquel FJ, Umpierrez GE. Hyperosmolar hyperglycemic state: a historic review of the clinical presentation, diagnosis, and treatment. Diabetes Care 2014;37(11):3124–3131. [PMC free article] [PubMed] [Google Scholar]

21. Fadini GP, de Kreutzenberg SV, Rigato M, et al. Characteristics and outcomes of the hyperglycemic hyperosmolar non-ketotic syndrome in a cohort of 51 consecutive cases at a single center. Diabetes Res Clin Pract 2011;94(2):172–179. [PubMed] [Google Scholar]

22. Wang ZH, Kihl-Selstam E, Eriksson JW. Ketoacidosis occurs in both Type 1 and Type 2 diabetes--a population-based study from Northern Sweden. Diabet Med 2008;25(7):867–870. [PubMed] [Google Scholar]

23. Karges B, Rosenbauer J, Holterhus PM, et al. Hospital admission for diabetic ketoacidosis or severe hypoglycemia in 31,330 young patients with type 1 diabetes. Eur J Endocrinol 2015;173(3):341–350. [PubMed] [Google Scholar]

24. Maahs DM, Hermann JM, Holman N, et al. Rates of diabetic ketoacidosis: international comparison with 49,859 pediatric patients with type 1 diabetes from England, Wales, the U.S., Austria, and Germany. Diabetes Care 2015;38(10):1876–1882. [PubMed] [Google Scholar]

25. Miller KM, Foster NC, Beck RW, et al. Current state of type 1 diabetes treatment in the U.S.: updated data from the T1D Exchange clinic registry. Diabetes Care 2015;38(6):971–978. [PubMed] [Google Scholar]

26. Rosenbloom AL. Hyperglycemic hyperosmolar state: an emerging pediatric problem. J Pediatr 2010;156(2):180–184. [PubMed] [Google Scholar]

27. Savage MW, Dhatariya KK, Kilvert A, et al. Joint British Diabetes Societies guideline for the management of diabetic ketoacidosis. Diabet Med 2011;28(5):508–515. [PubMed] [Google Scholar]

28. Otieno CF, Kayima JK, Omonge EO, Oyoo GO. Diabetic ketoacidosis: risk factors, mechanisms and management strategies in sub-Saharan Africa: a review. East Afr Med J 2005;82(12 Suppl):S197–203. [PubMed] [Google Scholar]

29. Bhowmick SK, Levens KL, Rettig KR. Hyperosmolar hyperglycemic crisis: an acute life-threatening event in children and adolescents with type 2 diabetes mellitus. Endocr Pract 2005;11(1):23–29. [PubMed] [Google Scholar]

30. Wachtel TJ, Silliman RA, Lamberton P. Prognostic factors in the diabetic hyperosmolar state. J Am Geriatr Soc 1987;35(8):737–741. [PubMed] [Google Scholar]

31. Basu A, Close CF, Jenkins D, Krentz AJ, Nattrass M, Wright AD. Persisting mortality in diabetic ketoacidosis. Diabet Med 1993;10(3):282–284. [PubMed] [Google Scholar]

32. Malone ML, Gennis V, Goodwin JS. Characteristics of diabetic ketoacidosis in older versus younger adults. J Am Geriatr Soc 1992;40(11):1100–1104. [PubMed] [Google Scholar]

33. Gibb FW, Teoh WL, Graham J, Lockman KA. Risk of death following admission to a UK hospital with diabetic ketoacidosis. Diabetologia 2016. [PMC free article] [PubMed]

34. Huang CC, Weng SF, Tsai KT, et al. Long-term Mortality Risk After Hyperglycemic Crisis Episodes in Geriatric Patients With Diabetes: A National Population-Based Cohort Study. Diabetes care 2015;38(5):746–751. [PubMed] [Google Scholar]

35. Gregg EW, Williams DE, Geiss L. Changes in diabetes-related complications in the United States. N Engl J Med 2014;371(3):286–287. [PubMed] [Google Scholar]

36. Javor KA, Kotsanos JG, McDonald RC, Baron AD, Kesterson JG, Tierney WM. Diabetic ketoacidosis charges relative to medical charges of adult patients with type I diabetes. Diabetes Care 1997;20(3):349–354. [PubMed] [Google Scholar]

37. Klingensmith GJ, Tamborlane WV, Wood J, et al. Diabetic ketoacidosis at diabetes onset: still an all too common threat in youth. J Pediatr 2013;162(2):330–334 e331. [PubMed] [Google Scholar]

38. Dabelea D, Rewers A, Stafford JM, et al. Trends in the prevalence of ketoacidosis at diabetes diagnosis: the SEARCH for diabetes in youth study. Pediatrics 2014;133(4):e938–945. [PMC free article] [PubMed] [Google Scholar]

39. Randall L, Begovic J, Hudson M, et al. Recurrent diabetic ketoacidosis in inner-city minority patients: behavioral, socioeconomic, and psychosocial factors. Diabetes Care 2011;34(9):1891–1896. [PMC free article] [PubMed] [Google Scholar]

40. Maldonado MR, Chong ER, Oehl MA, Balasubramanyam A. Economic impact of diabetic ketoacidosis in a multiethnic indigent population: analysis of costs based on the precipitating cause. Diabetes Care 2003;26(4):1265–1269. [PubMed] [Google Scholar]

41. Musey VC, Lee JK, Crawford R, Klatka MA, McAdams D, Phillips LS. Diabetes in urban African-Americans. I. Cessation of insulin therapy is the major precipitating cause of diabetic ketoacidosis. Diabetes Care 1995;18(4):483–489. [PubMed] [Google Scholar]

42. Umpierrez G, Freire AX. Abdominal pain in patients with hyperglycemic crises. J Crit Care 2002;17(1):63–67. [PubMed] [Google Scholar]

43. Barnard KD, Skinner TC, Peveler R. The prevalence of co-morbid depression in adults with Type 1 diabetes: systematic literature review. Diabet Med 2006;23(4):445–448. [PubMed] [Google Scholar]

44. Canadian Diabetes Association Clinical Practice Guidelines Expert C, Goguen J, Gilbert J. Hyperglycemic emergencies in adults. Can J Diabetes 2013;37 Suppl 1:S72–76. [PubMed] [Google Scholar]

45. Garg SK, Walker AJ, Hoff HK, D’Souza AO, Gottlieb PA, Chase HP. Glycemic parameters with multiple daily injections using insulin glargine versus insulin pump. Diabetes Technol Ther 2004;6(1):9–15. [PubMed] [Google Scholar]

46. Implementation of treatment protocols in the Diabetes Control and Complications Trial. Diabetes Care 1995;18(3):361–376. [PubMed] [Google Scholar]

47. Ly TT, Nicholas JA, Retterath A, Lim EM, Davis EA, Jones TW. Effect of sensor-augmented insulin pump therapy and automated insulin suspension vs standard insulin pump therapy on hypoglycemia in patients with type 1 diabetes: a randomized clinical trial. JAMA 2013;310(12):1240–1247. [PubMed] [Google Scholar]

48. Johnson SR, Cooper MN, Jones TW, Davis EA. Long-term outcome of insulin pump therapy in children with type 1 diabetes assessed in a large population-based case-control study. Diabetologia 2013;56(11):2392–2400. [PubMed] [Google Scholar]

49. Wachtel TJ, Tetu-Mouradjian LM, Goldman DL, Ellis SE, O’Sullivan PS. Hyperosmolarity and acidosis in diabetes mellitus: a three-year experience in Rhode Island. J Gen Intern Med 1991;6(6):495–502. [PubMed] [Google Scholar]

50. Gerich JE, Martin MM, Recant L. Clinical and metabolic characteristics of hyperosmolar nonketotic coma. Diabetes 1971;20(4):228–238. [PubMed] [Google Scholar]

51. Ben Salem C, Fathallah N, Hmouda H, Bouraoui K. Drug-induced hypoglycaemia: an update. Drug Saf 2011;34(1):21–45. [PubMed] [Google Scholar]

52. Caro JJ, Ward A, Levinton C, Robinson K. The risk of diabetes during olanzapine use compared with risperidone use: a retrospective database analysis. J Clin Psychiatry 2002;63(12):1135–1139. [PubMed] [Google Scholar]

53. Buse JB, Cavazzoni P, Hornbuckle K, Hutchins D, Breier A, Jovanovic L. A retrospective cohort study of diabetes mellitus and antipsychotic treatment in the United States. J Clin Epidemiol 2003;56(2):164–170. [PubMed] [Google Scholar]

54. Gianfrancesco F, Grogg A, Mahmoud R, Wang RH, Meletiche D. Differential effects of antipsychotic agents on the risk of development of type 2 diabetes mellitus in patients with mood disorders. Clin Ther 2003;25(4):1150–1171. [PubMed] [Google Scholar]

55. Ananth J, Parameswaran S, Gunatilake S. Side effects of atypical antipsychotic drugs. Curr Pharm Des 2004;10(18):2219–2229. [PubMed] [Google Scholar]

56. Lipscombe LL, Austin PC, Alessi-Severini S, et al. Atypical antipsychotics and hyperglycemic emergencies: multicentre, retrospective cohort study of administrative data. Schizophr Res 2014;154(1–3):54–60. [PubMed] [Google Scholar]

57. Peters AL, Buschur EO, Buse JB, Cohan P, Diner JC, Hirsch IB. Euglycemic Diabetic Ketoacidosis: A Potential Complication of Treatment With Sodium-Glucose Cotransporter 2 Inhibition. Diabetes Care 2015. [PMC free article] [PubMed]

58. Taylor SI, Blau JE, Rother KI. Perspective: SGLT2 inhibitors may predispose to ketoacidosis. J Clin Endocrinol Metab 2015:jc20151884. [PMC free article] [PubMed]

59. Peters AL, Buschur EO, Buse JB, Cohan P, Diner JC, Hirsch IB. Euglycemic Diabetic Ketoacidosis: A Potential Complication of Treatment With Sodium-Glucose Cotransporter 2 Inhibition. Diabetes Care 2015;38(9):1687–1693. [PMC free article] [PubMed] [Google Scholar]

60. Erondu N, Desai M, Ways K, Meininger G. Diabetic Ketoacidosis and Related Events in the Canagliflozin Type 2 Diabetes Clinical Program. Diabetes care 2015;38(9):1680–1686. [PMC free article] [PubMed] [Google Scholar]

61. Tang H, Li D, Wang T, Zhai S, Song Y. Effect of Sodium-Glucose Cotransporter 2 Inhibitors on Diabetic Ketoacidosis Among Patients With Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials. Diabetes care 2016;39(8):e123–124. [PubMed] [Google Scholar]

62. Kibbey RG. SGLT-2 inhibition and glucagon: Cause for alarm? Trends Endocrinol Metab 2015;26(7):337–338. [PMC free article] [PubMed] [Google Scholar]

63. Taylor SI, Blau JE, Rother KI. SGLT2 Inhibitors May Predispose to Ketoacidosis. The Journal of clinical endocrinology and metabolism 2015;100(8):2849–2852. [PMC free article] [PubMed] [Google Scholar]

64. Waldhausl W, Kleinberger G, Korn A, Dudczak R, Bratusch-Marrain P, Nowotny P. Severe hyperglycemia: effects of rehydration on endocrine derangements and blood glucose concentration. Diabetes 1979;28(6):577–584. [PubMed] [Google Scholar]

65. Chupin M, Charbonnel B, Chupin F. C-peptide blood levels in keto-acidosis and in hyperosmolar non-ketotic diabetic coma. Acta Diabetol Lat 1981;18(2):123–128. [PubMed] [Google Scholar]

66. Kitabchi AE, Umpierrez GE, Murphy MB, et al. Management of hyperglycemic crises in patients with diabetes. Diabetes care 2001;24(1):131–153. [PubMed] [Google Scholar]

67. Maldonado M, Hampe CS, Gaur LK, et al. Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes. J Clin Endocrinol Metab 2003;88(11):5090–5098. [PubMed] [Google Scholar]

68. Miles JM, Rizza RA, Haymond MW, Gerich JE. Effects of acute insulin deficiency on glucose and ketone body turnover in man: evidence for the primacy of overproduction of glucose and ketone bodies in the genesis of diabetic ketoacidosis. Diabetes 1980;29(11):926–930. [PubMed] [Google Scholar]

69. Foster DW, McGarry JD. The metabolic derangements and treatment of diabetic ketoacidosis. N Engl J Med 1983;309(3):159–169. [PubMed] [Google Scholar]

70. Laffel L Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev 1999;15(6):412–426. [PubMed] [Google Scholar]

71. Miles JM, Haymond MW, Nissen SL, Gerich JE. Effects of free fatty acid availability, glucagon excess, and insulin deficiency on ketone body production in postabsorptive man. J Clin Invest 1983;71(6):1554–1561. [PMC free article] [PubMed] [Google Scholar]

72. McGarry JD, Foster DW. Effects of exogenous fatty acid concentration on glucagon-induced changes in hepatic fatty acid metabolism. Diabetes 1980;29(3):236–240. [PubMed] [Google Scholar]

73. McGarry JD, Foster DW. Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem 1980;49:395–420. [PubMed] [Google Scholar]

74. Rains JL, Jain SK. Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med 2011;50(5):567–575. [PMC free article] [PubMed] [Google Scholar]

75. Li J, Huang M, Shen X. The association of oxidative stress and pro-inflammatory cytokines in diabetic patients with hyperglycemic crisis. J Diabetes Complications 2014;28(5):662–666. [PubMed] [Google Scholar]

76. Vaarala O, Yki-Jarvinen H. Diabetes: Should we treat infection or inflammation to prevent T2DM? Nat Rev Endocrinol 2012;8(6):323–325. [PubMed] [Google Scholar]

77. Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 2004;27(3):813–823. [PubMed] [Google Scholar]

78. Kim F, Tysseling KA, Rice J, et al. Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Arterioscler Thromb Vasc Biol 2005;25(5):989–994. [PubMed] [Google Scholar]

79. Chaudhuri A, Umpierrez GE. Oxidative stress and inflammation in hyperglycemic crises and resolution with insulin: implications for the acute and chronic complications of hyperglycemia. J Diabetes Complications 2012;26(4):257–258. [PMC free article] [PubMed] [Google Scholar]

80. Jenkins D, Close CF, Krentz AJ, Nattrass M, Wright AD. Euglycaemic diabetic ketoacidosis: does it exist? Acta diabetologica 1993;30(4):251–253. [PubMed] [Google Scholar]

81. Bas VN, Uytun S, Torun YA. Diabetic euglycemic ketoacidosis in newly diagnosed type 1 diabetes mellitus during Ramadan fasting. J Pediatr Endocrinol Metab 2015;28(3–4):333–335. [PubMed] [Google Scholar]

82. Guo RX, Yang LZ, Li LX, Zhao XP. Diabetic ketoacidosis in pregnancy tends to occur at lower blood glucose levels: case-control study and a case report of euglycemic diabetic ketoacidosis in pregnancy. J Obstet Gynaecol Res 2008;34(3):324–330. [PubMed] [Google Scholar]

83. Stephens JM, Sulway MJ, Watkins PJ. Relationship of blood acetoacetate and 3-hydroxybutyrate in diabetes. Diabetes 1971;20(7):485–489. [PubMed] [Google Scholar]

84. Sheikh-Ali M, Karon BS, Basu A, et al. Can serum beta-hydroxybutyrate be used to diagnose diabetic ketoacidosis? Diabetes Care 2008;31(4):643–647. [PubMed] [Google Scholar]

85. Arieff AI, Carroll HJ. Nonketotic hyperosmolar coma with hyperglycemia: clinical features, pathophysiology, renal function, acid-base balance, plasma-cerebrospinal fluid equilibria and the effects of therapy in 37 cases. Medicine (Baltimore) 1972;51(2):73–94. [PubMed] [Google Scholar]

86. Slovis CM, Mork VG, Slovis RJ, Bain RP. Diabetic ketoacidosis and infection: leukocyte count and differential as early predictors of serious infection. Am J Emerg Med 1987;5(1):1–5. [PubMed] [Google Scholar]

87. Beigelman PM. Potassium in severe diabetic ketoacidosis. The American journal of medicine 1973;54(4):419–420. [PubMed] [Google Scholar]

88. Adrogue HJ, Lederer ED, Suki WN, Eknoyan G. Determinants of plasma potassium levels in diabetic ketoacidosis. Medicine (Baltimore) 1986;65(3):163–172. [PubMed] [Google Scholar]

89. Umpierrez GE, DiGirolamo M, Tuvlin JA, Isaacs SD, Bhoola SM, Kokko JP. Differences in metabolic and hormonal milieu in diabetic- and alcohol-induced ketoacidosis. J Crit Care 2000;15(2):52–59. [PubMed] [Google Scholar]

90. Cahill GF Jr. Starvation in man. The New England journal of medicine 1970;282(12):668–675. [PubMed] [Google Scholar]

91. Umpierrez GE, Cuervo R, Karabell A, Latif K, Freire AX, Kitabchi AE. Treatment of diabetic ketoacidosis with subcutaneous insulin aspart. Diabetes Care 2004;27(8):1873–1878. [PubMed] [Google Scholar]

92. Hara JS, Rahbar AJ, Jeffres MN, Izuora KE. Impact of a hyperglycemic crises protocol. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2013;19(6):953–962. [PubMed] [Google Scholar]

93. Kitabchi AE, Umpierrez GE, Murphy MB, et al. Hyperglycemic crises in diabetes. Diabetes Care 2004;27 Suppl 1:S94–102. [PubMed] [Google Scholar]

94. May ME, Young C, King J. Resource utilization in treatment of diabetic ketoacidosis in adults. Am J Med Sci 1993;306(5):287–294. [PubMed] [Google Scholar]

95. Moss JM. Diabetic ketoacidosis: effective low-cost treatment in a community hospital. South Med J 1987;80(7):875–881. [PubMed] [Google Scholar]

96. Umpierrez GE, Latif KA, Cuervo R, Karabell A, Freire AX, Kitabchi AE. Subcutanbeous aspart insulin: a safe and cost effective treatment of diabetic ketoacidosis. Diabetes 2003;52(Suppl 1):584A. [Google Scholar]

97. Glaser NS, Ghetti S, Casper TC, Dean JM, Kuppermann N, Pediatric Emergency Care Applied Research Network DKAFSG. Pediatric diabetic ketoacidosis, fluid therapy, and cerebral injury: the design of a factorial randomized controlled trial. Pediatr Diabetes 2013;14(6):435–446. [PMC free article] [PubMed] [Google Scholar]

98. Van Zyl DG, Rheeder P, Delport E. Fluid management in diabetic-acidosis--Ringer’s lactate versus normal saline: a randomized controlled trial. QJM : monthly journal of the Association of Physicians 2012;105(4):337–343. [PubMed] [Google Scholar]

99. Umpierrez G, Korytkowski M. Diabetic emergencies - ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemia. Nat Rev Endocrinol 2016;12(4):222–232. [PubMed] [Google Scholar]

100. Abramson E, Arky R. Diabetic acidosis with initial hypokalemia. Therapeutic implications. JAMA : the journal of the American Medical Association 1966;196(5):401–403. [PubMed] [Google Scholar]

101. Lever E, Jaspan JB. Sodium bicarbonate therapy in severe diabetic ketoacidosis. Am J Med 1983;75(2):263–268. [PubMed] [Google Scholar]

102. Green SM, Rothrock SG, Ho JD, et al. Failure of adjunctive bicarbonate to improve outcome in severe pediatric diabetic ketoacidosis. Ann Emerg Med 1998;31(1):41–48. [PubMed] [Google Scholar]

103. Latif KA, Freire AX, Kitabchi AE, Umpierrez GE, Qureshi N. The use of alkali therapy in severe diabetic ketoacidosis. Diabetes Care 2002;25(11):2113–2114. [PubMed] [Google Scholar]

104. Gamba G, Oseguera J, Castrejon M, Gomez-Perez FJ. Bicarbonate therapy in severe diabetic ketoacidosis. A double blind, randomized, placebo controlled trial. Rev Invest Clin 1991;43(3):234–238. [PubMed] [Google Scholar]

105. Glaser N, Barnett P, McCaslin I, et al. Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. N Engl J Med 2001;344(4):264–269. [PubMed] [Google Scholar]

106. Fraley DS, Adler S. Correction of hyperkalemia by bicarbonate despite constant blood pH. Kidney Int 1977;12(5):354–360. [PubMed] [Google Scholar]

107. Umpierrez GE, Latif K, Stoever J, et al. Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis. Am J Med 2004;117(5):291–296. [PubMed] [Google Scholar]

108. Ersoz HO, Ukinc K, Kose M, et al. Subcutaneous lispro and intravenous regular insulin treatments are equally effective and safe for the treatment of mild and moderate diabetic ketoacidosis in adult patients. International journal of clinical practice 2006;60(4):429–433. [PubMed] [Google Scholar]

109. Karoli R, Fatima J, Salman T, Sandhu S, Shankar R. Managing diabetic ketoacidosis in non-intensive care unit setting: Role of insulin analogs. Indian J Pharmacol 2011;43(4):398–401. [PMC free article] [PubMed] [Google Scholar]

110. Kitabchi AE, Ayyagari V, Guerra SM. The efficacy of low-dose versus conventional therapy of insulin for treatment of diabetic ketoacidosis. Ann Intern Med 1976;84(6):633–638. [PubMed] [Google Scholar]

111. Hipszer B, Joseph J, Kam M. Pharmacokinetics of intravenous insulin delivery in humans with type 1 diabetes. Diabetes Technol Ther 2005;7(1):83–93. [PubMed] [Google Scholar]

112. Doshi P, Potter AJ, De Los Santos D, Banuelos R, Darger BF, Chathampally Y. Prospective randomized trial of insulin glargine in acute management of diabetic ketoacidosis in the emergency department: a pilot study. Acad Emerg Med 2015;22(6):657–662. [PubMed] [Google Scholar]

113. Hsia E, Seggelke S, Gibbs J, et al. Subcutaneous administration of glargine to diabetic patients receiving insulin infusion prevents rebound hyperglycemia. J Clin Endocrinol Metab 2012;97(9):3132–3137. [PubMed] [Google Scholar]

114. Umpierrez GE, Jones S, Smiley D, et al. Insulin analogs versus human insulin in the treatment of patients with diabetic ketoacidosis: a randomized controlled trial. Diabetes Care 2009;32(7):1164–1169. [PMC free article] [PubMed] [Google Scholar]

115. Wolfsdorf J, Glaser N, Sperling MA, American Diabetes A. Diabetic ketoacidosis in infants, children, and adolescents: A consensus statement from the American Diabetes Association. Diabetes care 2006;29(5):1150–1159. [PubMed] [Google Scholar]

116. Hoffman WH, Stamatovic SM, Andjelkovic AV. Inflammatory mediators and blood brain barrier disruption in fatal brain edema of diabetic ketoacidosis. Brain Res 2009;1254:138–148. [PubMed] [Google Scholar]

117. Glaser NS, Wootton-Gorges SL, Buonocore MH, et al. Subclinical cerebral edema in children with diabetic ketoacidosis randomized to 2 different rehydration protocols. Pediatrics 2013;131(1):e73–80. [PMC free article] [PubMed] [Google Scholar]

118. Shabbir N, Oberfield SE, Corrales R, Kairam R, Levine LS. Recovery from symptomatic brain swelling in diabetic ketoacidosis. Clin Pediatr (Phila) 1992;31(9):570–573. [PubMed] [Google Scholar]

119. Roberts MD, Slover RH, Chase HP. Diabetic ketoacidosis with intracerebral complications. Pediatr Diabetes 2001;2(3):109–114. [PubMed] [Google Scholar]

120. Kamat P, Vats A, Gross M, Checchia PA. Use of hypertonic saline for the treatment of altered mental status associated with diabetic ketoacidosis. Pediatr Crit Care Med 2003;4(2):239–242. [PubMed] [Google Scholar]

121. Marcin JP, Glaser N, Barnett P, et al. Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema. J Pediatr 2002;141(6):793–797. [PubMed] [Google Scholar]

122. Roe TF, Crawford TO, Huff KR, Costin G, Kaufman FR, Nelson MD Jr. Brain infarction in children with diabetic ketoacidosis. Journal of diabetes and its complications 1996;10(2):100–108. [PubMed] [Google Scholar]

123. Keane S, Gallagher A, Ackroyd S, McShane MA, Edge JA. Cerebral venous thrombosis during diabetic ketoacidosis. Arch Dis Child 2002;86(3):204–205. [PMC free article] [PubMed] [Google Scholar]

124. Rosenbloom AL. Intracerebral crises during treatment of diabetic ketoacidosis. Diabetes care 1990;13(1):22–33. [PubMed] [Google Scholar]

125. Deeb A, Yousef H, Abdelrahman L, et al. Implementation of a Diabetes Educator Care Model to Reduce Paediatric Admission for Diabetic Ketoacidosis. J Diabetes Res 2016;2016:3917806. [PMC free article] [PubMed] [Google Scholar]

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Precipitating causes of Diabetic Ketoacidosis by Country.