What is the primary distinction between the multiregional hypothesis and the Out of Africa hypothesis?

1. Darwin C. The Descent of Man, and Selection in Relation to Sex. London: John Murray; 1871. [Google Scholar]

2. Huxley TH. Evidence as to Man’s Place in Nature. London: Williams & Norgate; 1863. pp. 114–5. [Google Scholar]

3. Weidenreich F. Some problems dealing with ancient man. Am Anthropol. 1940;42:380–2. [Google Scholar]

4. Templeton AR. Genetics and recent human evolution. Evolution. 2007;61:1507–19. [PubMed] [Google Scholar]

5. Coon CS. The Origin of Races. New York, NY: Knopf; 1962. [Google Scholar]

6. Wu X. The well preserved cranium of an early Homo sapiens from Dali, Shanxi. Sciencia Sinica. 1981;2:200–6. [Google Scholar]

7. Stringer CB, Andrews P. Genetic and fossil evidence for the origin of modern humans. Science. 1988;239:1263–8. [PubMed] [Google Scholar]

8. Stringer CB. Replacement, continuity and the origin of Homo sapiens. In: Brauer G, Smith FH, editors. Continuity or Replacement? Controversies in Homo sapiens Evolution. Rotterdam: Balkema; 1992. pp. 9–24. [Google Scholar]

9. Zietkiewicz E, Yotova V, Gehl D, et al. Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern human diversity. Am J Hum Genet. 2003;73:994–1015. [PMC free article] [PubMed] [Google Scholar]

10. Sankararaman S, Mallick S, Dannemann M, et al. The genomic landscape of neanderthal ancestry in present-day humans. Nature. 2014;507:354–7. [PMC free article] [PubMed] [Google Scholar]

11. Ingman M, Kaessmann H, Pääbo S, Gyllensten U. Mitochondrial genome variation and the origin of modern humans. Nature. 2000;408:708–13. [PubMed] [Google Scholar]

12. Stringer C. Modern human origins: progress and prospects. Philos Trans R Soc Lond B Biol Sci. 2002;357:563–79. [PMC free article] [PubMed] [Google Scholar]

13. Cavalli-Sforza L, Feldman MW. The application of molecular genetic approaches to the study of human evolution. Nat Genet. 2003;33:266–75. [PubMed] [Google Scholar]

14. Relethford JH. Genetic evidence and the modern human origins debate. Heredity. 2008;100:555–63. [PubMed] [Google Scholar]

15. Tattersall I. Human origins: out of Africa. Proc Natl Acad Sci U S A. 2009;106:16018–21. [PMC free article] [PubMed] [Google Scholar]

16. Cann RL, Stoneking M, Wilson AC. Mitochondrial DNA and human evolution. Nature. 1987;325:31–6. [PubMed] [Google Scholar]

17. Vigilant L, Stoneking M, Harpending H, Hawkes K, Wilson AC. African populations and the evolution of human mitochondrial DNA. Science. 1991;253:1503–7. [PubMed] [Google Scholar]

18. Horai S, Hayasaka K, Kondo R, Tsugane K, Takahata N. Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs. Proc Natl Acad Sci U S A. 1995;92:532–6. [PMC free article] [PubMed] [Google Scholar]

19. Macaulay V, Hill C, Achilli A, et al. Single, rapid coastal settlement of Asia revealed by analysis of complete mitochondrial genomes. Science. 2005;308:1034–6. [PubMed] [Google Scholar]

20. Metspalu M, Kivisild T, Metspalu E, et al. Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans. BMC Genet. 2004;5:26. [PMC free article] [PubMed] [Google Scholar]

21. Ovchinnikov IV, Götherström A, Romanova GP, Kraritonov VM, Lidén K, Goodwin W. Molecular analysis of Neanderthal DNA from the northern caucasus. Nature. 2000;404:490–3. [PubMed] [Google Scholar]

22. Relethford JH. Absence of regional affinities of Neandertal DNA with living humans does not reject multiregional evolution. Am J Phys Anthropol. 2001;115:95–8. [PubMed] [Google Scholar]

23. Caramelli D, Lalueza-Fox C, Vernesi C, et al. Evidence for a genetic discontinuity between Neandertals and 24,000-year-old anatomically modern Europeans. Proc Natl Acad Sci U S A. 2003;100:6593–7. [PMC free article] [PubMed] [Google Scholar]

24. Thomson R, Pritchard JK, Shen P, Oefner PJ, Feldman MW. Recent common ancestry of human Y chromosomes: evidence from DNA sequence data. Proc Natl Acad Sci U S A. 2000;97:7360–5. [PMC free article] [PubMed] [Google Scholar]

25. Underhill PA, Shen P, Lin AA, et al. Y chromosome sequence variation and the history of human populations. Nat Genet. 2000;26:358–61. [PubMed] [Google Scholar]

26. Hawks J. The Y chromosome and the replacement hypothesis. Science. 2001;293:567. [PubMed] [Google Scholar]

27. Takahata N, Lee SH, Satta Y. Testing multiregionality of modern human origins. Mol Biol Evol. 2001;18:172–83. [PubMed] [Google Scholar]

28. Alonso S, Armour JA. A highly variable segment of human subterminal 16p reveals a history of population growth for modern humans outside Africa. Proc Natl Acad Sci U S A. 2001;98:864–9. [PMC free article] [PubMed] [Google Scholar]

29. Rosenberg NA, Pritchard JK, Weber JL, et al. Genetic structure of human populations. Science. 2002;298:2381–5. [PubMed] [Google Scholar]

30. Zhivotovsky LA, Rosenberg NA, Feldman MW. Features of evolution and expansion of modern humans, inferred from genomewide microsatellite markers. Am J Hum Genet. 2003;72:1171–86. [PMC free article] [PubMed] [Google Scholar]

31. Prugnolle F, Manica A, Balloux F. Geography predicts neutral genetic diversity of human populations. Curr Biol. 2005;15:159–60. [PMC free article] [PubMed] [Google Scholar]

32. Ramachandran S, Deshpande O, Roseman CC, Rosenberg NA, Feldman MW, Cavalli-Sforza LL. Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa. Proc Natl Acad Sci U S A. 2005;102:15942–7. [PMC free article] [PubMed] [Google Scholar]

33. Harding RM, McVean G. A structured ancestral population for the evolution of modern humans. Curr Opin Genet Dev. 2004;14:1–8. [PubMed] [Google Scholar]

34. Goldstein DB, Chikhi L. Human migrations and population structure: what we know and why it matters. Annu Rev Genomics Hum Genet. 2002;3:129–52. [PubMed] [Google Scholar]

35. Excoffier L. Human demographic history: refining the recent African origin model. Curr Opin Genet Dev. 2002;12:675–82. [PubMed] [Google Scholar]

36. Watkins WS, Rogers AR, Ostler CT, et al. Genetic variation among world populations: inferences from 100 Alu insertion polymorphisms. Genome Res. 2003;13:1607–18. [PMC free article] [PubMed] [Google Scholar]

37. Labuda D, Zietkiewicz E, Yotova V. Archaic lineages in the history of modern humans. Genetics. 2000;156:799–808. [PMC free article] [PubMed] [Google Scholar]

38. Satta Y, Takahata N. The distribution of the ancestral haplotype in finite stepping-stone models with population expansion. Mol Ecol. 2004;13:877–86. [PubMed] [Google Scholar]

39. Eriksson A, Manica A. Effect of ancient population structure on the degree of polymorphism shared between modern human populations and ancient hominins. Proc Natl Acad Sci U S A. 2012;109:13956–60. [PMC free article] [PubMed] [Google Scholar]

40. Eriksson A, Manica A. The doubly conditioned frequency spectrum does not distinguish between ancient population structure and hybridisation. Mol Biol Evol. 2014;31:1618–21. [PMC free article] [PubMed] [Google Scholar]

41. Lowery RK, Uribe G, Jimenez EB, et al. Neanderthal and Denisova genetic affinities with contemporary humans: introgression versus common ancestral polymorphisms. Gene. 2013;530:83–94. [PubMed] [Google Scholar]

42. Gunz P, Bookstein FL, Mitteroecker P, Stadlmayr A, Seidler H, Weber GW. Early modern human diversity suggests subdivided population structure and a complex out-of-Africa scenario. Proc Natl Acad Sci U S A. 2009;106:6094–8. [PMC free article] [PubMed] [Google Scholar]

43. Scerri EML, Drake NA, Jennings R, Groucutt HS. Earliest evidence for the structure of Homo sapiens populations in Africa. Quat Sci Rev. 2014;101:207–16. [Google Scholar]

44. McDougall I, Brown FH, Fleagle JG. Stratigraphic placement and age of modern humans from Kibish, Ethiopia. Nature. 2005;433:733–6. [PubMed] [Google Scholar]

45. Clark JD, Beyene Y, WoldeGabriel G, et al. Stratigraphic, chronological and behavioural contexts of Pleistocene Homo sapiens from Middle Awash, Ethiopia. Nature. 2003;423:747–52. [PubMed] [Google Scholar]

46. McCarthy RC, Lucas LA. Morphometric re-assessment of BOU-VP-16/1 from Herto, Ethiopia. J Hum Evol. 2014;74:114–7. [PubMed] [Google Scholar]

47. Henn BM, Gignoux CR, Jobin M, et al. Hunter-gatherer genomic diversity suggests a southern African origin for modern humans. Proc Natl Acad Sci U S A. 2011;108:5154–62. [PMC free article] [PubMed] [Google Scholar]

48. Schlebusch CM, Skoglund P, Sjödin P, et al. Genomic variation in seven Khoe-San groups reveals adaptation and complex African history. Science. 2012;338:374–9. [PMC free article] [PubMed] [Google Scholar]

49. Pickrell JK, Patterson N, Barbieri C, et al. The genetic prehistory of southern Africa. Nat Commun. 2012;3:1143. [PMC free article] [PubMed] [Google Scholar]

50. Kim HL, Ratan A, Perry GH, Montenegro A, Miller W, Schuster SC. Khoisan hunter-gatherers have been the largest population throughout most of modern-human demographic history. Nat Commun. 2014;5:5692. [PMC free article] [PubMed] [Google Scholar]

51. Blome MW, Cohen AS, Tryon CA, Brooks AS, Russell J. The environmental context for the origins of modern human diversity: a synthesis of regional variability in African climate 150,000–30,000 years ago. J Hum Evol. 2012;62:563–92. [PubMed] [Google Scholar]

52. Rito T, Richards MB, Fernandes V, et al. The first modern human dispersals across Africa. PLoS One. 2013;8:e80031. [PMC free article] [PubMed] [Google Scholar]

53. Smith TM, Tafforeau P, Reid DJ, et al. Earliest evidence of modern humans life history in North African early. Homo sapiens. Proc Natl Acad Sci U S A. 2007;104:6128–33. [PMC free article] [PubMed] [Google Scholar]

54. Cruciani F, Trombetta B, Massaia A, Destro-Bisol G, Sellitto D, Scozzari R. A revised root for the human Y chromosomal phylogenetic tree: the origin of patrilineal diversity in Africa. Am J Hum Genet. 2011;88(6):814–8. [PMC free article] [PubMed] [Google Scholar]

55. Fadhlaoui-Zid K, Haber M, Martínez-Cruz B, Zalloua P, Elgaaied AB, Comas D. Genome-wide and paternal diversity reveal a recent origin of human populations in North Africa. PLoS One. 2013;8:e80293. [PMC free article] [PubMed] [Google Scholar]

56. Hovers E. The Lithic Assemblages of Qafzeh Cave. New York, NY: Oxford University Press; 2009. [Google Scholar]

57. Grün R, Stringer C, McDermott F, et al. U-series and ESR analyses of bones and teeth relating to the human burials from Skhul. J Hum Evol. 2005;49:316–34. [PubMed] [Google Scholar]

58. Oppenheimer S. Out of Eden: the Peopling of the World. London: Constable; 2003. [Google Scholar]

59. Hershkovitz I, Marder O, Ayalon A, et al. Levantine cranium from Manot Cave (Israel) foreshows the first European modern humans. Nature. 2015;520:216–9. [PubMed] [Google Scholar]

60. Pope KO, Terrell JE. Environmental setting of human migrations in the circum-Pacific region. J Biogeogr. 2008;35:1–21. [Google Scholar]

61. Kingdom J. Self-Made Man and His Undoing: The Radical Reworking of Evolution Theory. New York, NY: Simon & Schuster; 1993. [Google Scholar]

62. Groucutt HS, White TM, Clark-Balzan L, et al. Human occupation of the Arabian Empty Qarter during MIS 5: evidence from Mundafan Al-Buhayrah, Saudi Arabia. Quat Sci Rev. 2015;119:116–35. [Google Scholar]

63. Luis JR, Rowold DJ, Regueiro M, et al. The Levant versus the Horn of Africa: evidence for bidirectional corridors of human migrations. Am J Hum Genet. 2004;74:532–44. [PMC free article] [PubMed] [Google Scholar]

64. Pagani L, Schiffels S, Gurdasani D, et al. Tracing the route of modern humans out of Africa by using 225 human genome sequences from Ethiopians and Egyptians. Am J Hum Genet. 2015;96:986–91. [PMC free article] [PubMed] [Google Scholar]

65. Cavalli-Sforza LL, Piazza A, Menozzi P, Mountain J. Reconstruction of human evolution: bringing together genetic, archaeological, and linguistic data. Proc Natl Acad Sci U S A. 1988;85:6002–6. [PMC free article] [PubMed] [Google Scholar]

66. Quintana-Murci L, Semino O, Bandelt HJ, Passarino G, McElreavey K, Santachiara-Benerecetti AS. Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa. Nat Genet. 1999;23:437–41. [PubMed] [Google Scholar]

67. Soares P, Alshamali F, Pereira JB, et al. The expansion of mtDNA Haplogroup L3 within and out of Africa. Mol Biol Evol. 2012;29:915–27. [PubMed] [Google Scholar]

68. Forster P, Matsumura S. Did early humans go north or south? Science. 2005;308:965–6. [PubMed] [Google Scholar]

69. Reed FA, Tishkoff SA. African human diversity, origins and migrations. Curr Opin Genet Dev. 2006;16:597–605. [PubMed] [Google Scholar]

70. Torroni A, Achilli A, Macaulay V, Richards M, Bandelt H. Harvesting the fruit of the human mtDNA tree. Trends in Genetics. 2006;22:339–45. [PubMed] [Google Scholar]

71. Fernandes V, Alshamali F, Alves M, et al. The Arabian cradle: mitochondrial relicts of the first steps along the southern route out of Africa. Am J Hum Genet. 2012;90:347–55. [PMC free article] [PubMed] [Google Scholar]

72. Groucutt HS, Petraglia MD, Bailey G, et al. Rethinking the dispersal of Homo sapiens out of Africa. Evol Anthropol. 2015;24:149–64. [PMC free article] [PubMed] [Google Scholar]

73. Liu H, Prugnolle F, Manica A, Balloux F. A geographically explicit genetic model of worldwide human-settlement history. Am J Hum Genet. 2006;79:230–7. [PMC free article] [PubMed] [Google Scholar]

74. Oppenheimer S. Out-of-Africa, the peopling of continents and islands: tracing uniparental gene trees across the map. Proc Natl Acad Sci U S A. 2012;367:770–84. [PMC free article] [PubMed] [Google Scholar]

75. Walter RC, Buffer RT, Bruggemann JH, et al. Early human occupation of the Red Sea Coast of Eritrea during the last interglacial. Nature. 2000;405:65–9. [PubMed] [Google Scholar]

76. Rose JI. New light on human prehistory in the Arabo-Persian Gulf Oasis. Curr Anthropol. 2010;51:849–83. [Google Scholar]

77. Boivin N, Fuller DQ, Dennell R, Allaby R, Petraglia MD. Human dispersal across diverse environments of Asia during the Upper Pleistocene. Quat Int. 2013;300:32–47. [Google Scholar]

78. Mellars P, Gori KC, Carr M, Soares PA, Richards MB. Genetic and archaeological perspectives on the initial modern human colonization of Southern Asia. Proc Natl Acad Sci U S A. 2013;110:10699–704. [PMC free article] [PubMed] [Google Scholar]

79. Mellars P. Going east: new genetic and archaeological perspectives on the modern human colonization of Eurasia. Science. 2006;313:796–800. [PubMed] [Google Scholar]

80. Underhill PA, Kivisild T. Use of Y chromosome and mitochondrial DNA population structure in tracing human migrations. Ann Rev Genet. 2007;41:539–64. [PubMed] [Google Scholar]

81. O’Connell JF, Allen J. The restaurant at the end of the Universe: modelling the colonisation of Sahul. Aust Archaeol. 2012;74:5–31. [Google Scholar]

82. Shi W, Ayub Q, Vermeulen M, et al. A worldwide survey of human male demographic history based on Y-SNP and Y-STR data from the HGDP-CEPH populations. Mol Biol Evol. 2010;27:385–93. [PMC free article] [PubMed] [Google Scholar]

83. Stringer C. Palaeoanthropology. Coasting out of Africa. Nature. 2000;405(24–5):27. [PubMed] [Google Scholar]

84. Rampino MR, Self S. Volcanic winter and accelerated glaciation following the Toba super-eruption. Nature. 1992;359:50–2. [Google Scholar]

85. Petraglia M, Korisettar R, Boivin N, et al. Middle paleolithic assemblages from the Indian subcontinent before and after the Toba Super-Eruption. Science. 2007;317:114–6. [PubMed] [Google Scholar]

86. Armitage SJ, Jasim SA, Marks AE, Parker AG, Usik VI, Uerpmann H. The southern route “Out of Africa”: evidence for an early expansion of modern humans into Arabia. Science. 2011;331:453–6. [PubMed] [Google Scholar]

87. Rose JI, Usik VI, Marks AE, et al. The Nubian complex of Dhofar, Oman: an African Middle Stone Age industry in Southern Arabia. PLoS One. 2011;6:e28239. [PMC free article] [PubMed] [Google Scholar]

88. Liu W, Martinón-Torres M, Cai Y, et al. The earliest unequivocally modern humans in Southern China. Nature. 2015;526:696–9. [PubMed] [Google Scholar]

89. Liu W, Jin CZ, Zhang YQ, et al. Human remains from Zhirendong, South China, and modern human emergence in East Asia. Proc Natl Acad Sci U S A. 2010;107:19201–6. [PMC free article] [PubMed] [Google Scholar]

90. Bae CJ, Wang W, Zhao J, Huang S, Tian F, Shen G. Modern human teeth from Late Pleistocene Luna Cave (Guangxi, China) Quat Int. 2014;354:169–83. [Google Scholar]

91. Rosenberg K. A late Pleistocene human skeleton from Liujiang, China suggests regional population variation in sexual dimorphism in the human pelvis. Var Evol. 2002;10:5–17. [Google Scholar]

92. Mijares AS, Détroit F, Piper P, et al. New evidence for a 67,000-year-old human presence at Callao Cave, Luzon, Philippines. J Hum Evol. 2010;59:123–32. [PubMed] [Google Scholar]

93. Zhivotovsky LA, Bennett L, Bowcock AM, Feldman MW. Human population expansion and microsatellite variation. Mol Biol Evol. 2000;17:757–67. [PubMed] [Google Scholar]

94. Gravel S, Henn BM, Gutenkunst RN, et al. Demographic history and rare allele sharing among human populations. Proc Natl Acad Sci U S A. 2011;108:11983–8. [PMC free article] [PubMed] [Google Scholar]

95. Harris K, Nielsen R. Inferring demographic history from a spectrum of shared haplotype lengths. PLoS Genet. 2013;9:e1003521. [PMC free article] [PubMed] [Google Scholar]

96. Gronau I, Hubisz MJ, Gulko B, Danko CG, Siepel A. Bayesian inference of ancient human demography from individual genome sequences. Nat Genet. 2011;43:1031–4. [PMC free article] [PubMed] [Google Scholar]

97. Li H, Durbin R. Inference of human population history from individual whole-genome sequences. Nature. 2011;13:493–6. [PMC free article] [PubMed] [Google Scholar]

98. Scally A, Durbin R. Revisiting the human mutation rate: implications for understanding human evolution. Nat Rev Genet. 2012;13:745–53. [PubMed] [Google Scholar]

99. Schiffels S, Durbin R. Inferring human population size and separation history from multiple genome sequences. Nat Genet. 2014;46:919–25. [PMC free article] [PubMed] [Google Scholar]

100. Roach JC, Glusman G, Smit AF, et al. Analysis of genetic inheritance in a family quartet by whole-genome sequencing. Science. 2010;328:636–9. [PMC free article] [PubMed] [Google Scholar]

101. Conrad DF, Keebler JE, DePristo MA, et al. Variation in genome-wide mutation rates within and between human families. Nat Genet. 2011;43:712–4. [PMC free article] [PubMed] [Google Scholar]

102. Kong A, Frigge ML, Masson G, et al. Rate of de novo mutations and the importance of father’s age to disease risk. Nature. 2012;488:471–5. [PMC free article] [PubMed] [Google Scholar]

103. Campbell CD, Chong JX, Malig M, et al. Estimating the human mutation rate using autozygosity in a founder population. Nat Genet. 2012;44:1277–81. [PMC free article] [PubMed] [Google Scholar]

104. Besenbacher S, Liu S, Izarzugaza JM, et al. Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios. Nat Commun. 2015(6):5969. [PMC free article] [PubMed] [Google Scholar]

105. Harris K. Evidence for recent, population-specific evolution of the human mutation rate. Proc Natl Acad Sci U S A. 2015;112:3439–44. [PMC free article] [PubMed] [Google Scholar]

106. Lipson M, Loh P, Sankararaman S, Patterson N, Berger B, Reich D. Calibrating the human mutation rate via ancestral recombindation density in diploid genomes. PLoS Genet. 2015;11:e1005550. [PMC free article] [PubMed] [Google Scholar]

107. Fu Q, Mittnik A, Johnson PLF, et al. A revised timescale for human evolution based on ancient mitochondrial genomes. Curr Biol. 2013;23(7):553–9. [PMC free article] [PubMed] [Google Scholar]

108. Fu Q, Li H, Moorjani P, et al. Genome sequence of a 45,000-year-old modern human from Western Siberia. Nature. 2014;514:445–9. [PMC free article] [PubMed] [Google Scholar]

109. Prüfer K, Racimo F, Patterson N, et al. The complete genome sequence of a Neanderthal from the Altai mountains. Nature. 2014;505:43–9. [PMC free article] [PubMed] [Google Scholar]

110. Reich D, Green RE, Kircher M, et al. genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature. 2010;468:1053–60. [PMC free article] [PubMed] [Google Scholar]

111. Meyer M, Kircher M, Gansauge MT, et al. A high-coverage genome sequence from an archaic Denisovan individual. Science. 2012;338:222–6. [PMC free article] [PubMed] [Google Scholar]

112. Hublin JJ. The origin of Neandertals. Proc Natl Acad Sci U S A. 2009;106:16022–7. [PMC free article] [PubMed] [Google Scholar]

113. Finlayson C, Pacheco FG, Rodríguez-Vidal J, et al. Late survival of Neanderthals at the southernmost extreme of Europe. Nature. 2006;443:850–3. [PubMed] [Google Scholar]

114. Krings M, Stone A, Schmitz RW, et al. Neanderthal DNA sequences and the origin of modern humans. Cell. 1997;90:19–30. [PubMed] [Google Scholar]

115. Currat M, Excoffier L. Modern humans did not admix with Neanderthals during their range expansion into Europe. PLoS Biol. 2004;2:e421. [PMC free article] [PubMed] [Google Scholar]

116. Serre D, Langaney A, Chech M, et al. No evidence of Neandertal mtDNA contribution to early modern humans. PLoS Biol. 2004;2:e57. [PMC free article] [PubMed] [Google Scholar]

117. Green R, Malaspinas A-S, Krause J, et al. A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing. Cell. 2008;134:416–26. [PMC free article] [PubMed] [Google Scholar]

118. Green RE, Krause J, Briggs AW, et al. A draft sequence of the Neandertal genome. Science. 2010;328:710–22. [PMC free article] [PubMed] [Google Scholar]

119. Sankararaman S, Patterson N, Li H, Pääbo S, Reich D. The date of interbreeding between Neandertals and modern humans. PLoS Genet. 2012;8:e1002947. [PMC free article] [PubMed] [Google Scholar]

120. Patterson NJ, Moorjani O, Luo Y, et al. Ancent admixture in human history. Genetics. 2012;192:1065–93. [PMC free article] [PubMed] [Google Scholar]

121. Durand EY, Patterson N, Reich D, Slatkin M. Testing for ancient admixture between closely related populations. Mol Biol Evol. 2011;28:2239–52. [PMC free article] [PubMed] [Google Scholar]

122. Trinkaus E, Moldovan O, Milota S, et al. An early modern human from the Pestera Cu Oase, Romania. Proc Natl Acad Sci U S A. 2003;110:11231–36. [PMC free article] [PubMed] [Google Scholar]

123. Fu Q, Hajdinjak M, Moldovan OT, et al. An early modern human from Romania with a recent Neanderthal ancestor. Nature. 2015;524:216–9. [PMC free article] [PubMed] [Google Scholar]

124. Kuhlwilm M, Gronau I, Hubisz MJ, et al. Ancient gene flow from early modern humans into Eastern Neanderthals. Nature. 2016;530(7591):429–33. [PMC free article] [PubMed] [Google Scholar]

125. Reich D, Patterson N, Kircher M, et al. Denisova admixture and the first modern human dispersals into Southeast Asia and Oceania. Am J Hum Genet. 2011;89:516–28. [PMC free article] [PubMed] [Google Scholar]

126. Qin P, Stoneking M. Denisovan ancestry in East Eurasian and native American populations. Mol Biol Evol. 2015;32:2665–74. [PubMed] [Google Scholar]

127. Huerta-Sánchez E, Jin X, Asan, et al. Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA. Nature. 2014;512:194–7. [PMC free article] [PubMed] [Google Scholar]

128. Klein RG. The Human Career: Human Biological and Cultural Origins. Chicago: Chicago University Press; 2009. [Google Scholar]

129. Shea JJ. The archaeology of an illusion: the middle-upper paleolithic transition in the Levant. In: Le Tenesor JM, Jagher R, Otte R, editors. The Lower and Middle Paleolithic in the Middle East and Neighbouring Regions. ERAUL 126. Liége: Université de Liége; 2011. pp. 169–82. [Google Scholar]

130. McDermott F, Grun R, Stringer GB, Hawkesworth CJ. Mass spectrometric dates for Israeli Neanderthal/early modern sites. Nature. 1993;363:252–5. [PubMed] [Google Scholar]

131. Frumkin A, Bar-Yosef O, Schwarcz HP. Possibly paleohydrologic and paleo-climatic effects on hominin migration and occupation of the Levantine Middle Paleolithic. J Hum Evol. 2011;60:427–51. [PubMed] [Google Scholar]

132. Oppenheimer S. A single southern exit of modern humans from Africa: before or after Toba? Quat Int. 2012;258:88–99. [Google Scholar]

133. Usik VI, Rose JI, Hilbert YH, et al. Nubian complex reduction strategies in Dhofar, Southern Oman. Quat Int. 2013;300:244–66. [Google Scholar]

134. Deshpande O, Batzoglo S, Feldman MW, Cavalli-Sforza LL. A serial founder effect model for human settlement out of Africa. Proc Biol Sci. 2009;276:291–300. [PMC free article] [PubMed] [Google Scholar]

135. Pemberton TJ, DeGiorgio M, Rosenberg NA. Population structure in a comprehensive set on human microsatellite variation. G3 (Bethesda) 2013;3:891–907. [PMC free article] [PubMed] [Google Scholar]

136. Pickrell J, Reich D. Towards a new history and geography of human genes informed by ancient DNA. Trends Genet. 2014;30:377–89. [PMC free article] [PubMed] [Google Scholar]

137. Gutenkunst RN, Hernandez RD, Williamson SH, Bustamante CD. Inferring the joint demographic history of multiple populations from multidimensional SNP frequency data. PLoS Genet. 2009;5:e1000695. [PMC free article] [PubMed] [Google Scholar]

138. Keinan A, Mullikin JC, Patterson N, Reich D. Accelerated genetic drift on chromosome X during the human dispersal out of Africa. Nat Genet. 2009;41:66–70. [PMC free article] [PubMed] [Google Scholar]

139. Bowler JM, Jones R, Allen H, Thorne AG. Pleistocene remains from Australia: a living site and human cremation from Lake Mungo, Western New South Wales. World Archaeol. 1970;1:39–60. [PubMed] [Google Scholar]

140. Wollstein A, Lao O, Becker C, et al. Demographic history of Oceania inferred from genome-wide data. Curr Biol. 2010;20:1983–92. [PubMed] [Google Scholar]

141. Lahr M, Foley R. Multiple dispersals and modern human origins. Evol Anthropol. 1994;3:48–60. [Google Scholar]

142. Lahr M, Foley R. Towards a theory of modern human origins: geography, demography and diversity in recent human evolution. Am J Phys Anthropol. 1998;41:137–76. [PubMed] [Google Scholar]

143. Field JS, Lahr MM. Assessment of the southern dispersal: GIS-based analysis of potential routes at oxygen isotopic stage 4. J World Prehistory. 2006;19:1–45. [Google Scholar]

144. McEvoy BP, Powell JE, Goddard ME, Visscher PM. Human population dispersal “Out of Africa” estimated from linkage disequilibrium and allele frequencies of SNPs. Genome Res. 2011;21:821–9. [PMC free article] [PubMed] [Google Scholar]

145. Tassi F, Ghirotto S, Mezzavilla M, Vilaça ST, de Santi L, Barbujani G. Early modern human dispersal from Africa: genomic evidence for multiple waves of migration. Investig Genet. 2015(6):13. [PMC free article] [PubMed] [Google Scholar]

146. Groube L, Chappell J, Muke J, Price D. A 40,000 year-old occupation site at Huon Peninsula, Papua New Guinea. Nature. 1986;324:453–5. [PubMed] [Google Scholar]

147. O’Connell JF, Allen J. Dating the colonization of Sahul (Pleistocene Australia-New Guinea): a review of recent research. J Archaeol Sci. 2004;31:835–53. [Google Scholar]

148. Bowler JM, Johnston H, Olley JM, et al. New ages for human occupation and climatic change at Lake Mungo, Australia. Nature. 2003;421:837–40. [PubMed] [Google Scholar]

149. Templeton A. Out of Africa again and again. Nature. 2002;416:45–51. [PubMed] [Google Scholar]

150. Reyes-Centeno H, Hubbe M, Hanihara T, Stringer C, Harvati K. Testing modern human out-of-Africa dispersal models and implications for modern human origins. J Hum Evol. 2015;87:95–106. [PubMed] [Google Scholar]

151. Reyes-Centeno H, Ghirotto S, Detroit F, Grimaud-Hervé D, Barbujani G, Harvati K. Genomic and cranial phenotype data support multiple modern human dispersals from Africa and a Southern route into Asia. Proc Natl Acad Sci U S A. 2014;111:7248–53. [PMC free article] [PubMed] [Google Scholar]

152. Reich D, Thangaraj K, Patterson N, Price AL, Singh L. Reconstructing Indian population history. Nature. 2009;461(489):494. [PMC free article] [PubMed] [Google Scholar]

153. Aghakhanian F, Yunus Y, Naidu R, et al. Unravelling the genetic history of Negritos and Indigenous populations of Southeast Asia. Genome Biol Evol. 2015;7:1206–15. [PMC free article] [PubMed] [Google Scholar]

154. Rasmussen M, Guo X, Wang Y, et al. An Aboriginal Australian genome reveals separate human dispersals into Asia. Science. 2011;334:94–8. [PMC free article] [PubMed] [Google Scholar]

155. Weaver TD. Tracing the paths of modern humans from Africa. Proc Natl Acad Sci U S A. 2014;111:7170–1. [PMC free article] [PubMed] [Google Scholar]

156. Skoglund P, Jakobsson M. Archaic human ancestry in East Asia. Proc Natl Acad Sci U S A. 2011;108:18301–6. [PMC free article] [PubMed] [Google Scholar]

157. Cooper A, Stringer CB. Did the Denisovans cross Wallace’s Line? Science. 2013;342:321–3. [PubMed] [Google Scholar]

158. Maca-Meyer N, Gonzalez AM, Larruga JM, Flores C, Cabrera VM. Major genomic mitochondrial lineages delineate early human expansions. BMC Genet. 2001(2):13. [PMC free article] [PubMed] [Google Scholar]

159. Gonzalez AM, Larruga JM, Abu-Amero KK, Shi Y, Pestano J, Cabrera VM. Mitochondrial lineage M1 traces an early human backflow to Africa. BMC Genomics. 2007(8):223. [PMC free article] [PubMed] [Google Scholar]

160. Pickrell JK, Patterson N, Loh PR, et al. Ancient west Eurasian ancestry in southern and eastern Africa. Proc Natl Acad Sci U S A. 2014;111:2632–7. [PMC free article] [PubMed] [Google Scholar]

161. Pagani L, Kivisild T, Tarekegn A, et al. Ethiopian genetic diversity reveals linguistic stratification and complex influences on the Ethiopian gene pool. Am J Hum Genet. 2012;91:83–96. [PMC free article] [PubMed] [Google Scholar]

162. Loh P-R, Lipson M, Patterson N, et al. Inferring admixture histories of human populations using linkage disequilibrium. Genetics. 2013;193:1233–54. [PMC free article] [PubMed] [Google Scholar]

163. Hellenthal G, Busby GB, Band G, et al. A genetic Atlas of human admixture history. Science. 2014;343:747–51. [PMC free article] [PubMed] [Google Scholar]

164. Henn BM, Botigué LR, Gravel S, et al. Genomic ancestry of North Africans supports back-to-Africa migrations. PLoS Genet. 2012;8:e1002397. [PMC free article] [PubMed] [Google Scholar]

165. Hodgson JA, Mulligan CJ, Al-Meeri A, Raaum RL. Early back-to-Africa migration into the Horn of Africa. PLoS Genet. 2014;10:e1004393. [PMC free article] [PubMed] [Google Scholar]

166. Cerný V, Mulligan CJ, Fernandes V, et al. Internal diversification of mitochondrial haplogroup R0a reveals post-last glacial maximum demographic expansions in South Arabia. Mol Biol Evol. 2011;28:71–8. [PubMed] [Google Scholar]

167. Musilová E, Fernandes V, Silva NM, et al. Population history of the Red Sea-genetic exchanges between the Arabian Peninsula and East Africa signaled in the mitochondrial DNA HV1 Haplogroup. Am J Phys Anthropol. 2011;145:592–8. [PubMed] [Google Scholar]

168. Non AL, Al-Meeri A, Raaum RL, Sanchez LF, Mulligan CJ. Mitochondrial DNA reveals distinct evolutionary histories for Jewish populations in Yemen and Ethiopia. Am J Phys Anthropol. 2011;144:1–10. [PubMed] [Google Scholar]

169. Pennarun E, Kivisild T, Metspalu E, et al. Divorcing the Late Upper Palaeolithic demographic histories of mtDNA haplogroups M1 and U6 in Africa. BMC Evol Biol. 2012(12):234. [PMC free article] [PubMed] [Google Scholar]

170. Keinan A, Mullikin J, Patterson N, Reich D. Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans. Nat Genet. 2007;39:1251–5. [PMC free article] [PubMed] [Google Scholar]

171. Llorente MG, Jones ER, Eriksson A, et al. Ancient Ethiopian genome reveals extensive Eurasian admixture throughout the African continent. Science. 2015;350(6262):820–2. [PubMed] [Google Scholar]

172. Smith CI, Chamberlain AT, Riley MS, Stringer C, Collins MJ. The thermal history of human fossils and the likelihood of successful DNA amplification. J Hum Evol. 2003;45:203–17. [PubMed] [Google Scholar]

173. Allentoft ME, Collins M, Harker D, et al. The half-life of DNA in bone: measuring decay kinetics in 158 dated fossils. Proc Biol Sci. 2012;279:4724–33. [PMC free article] [PubMed] [Google Scholar]