Axillary lymphadenopathy, also known as adenopathy, describes changes in the size and consistency of lymph nodes in the armpit (axillary lymph nodes). It is not a disease itself but rather a symptom associated with a range of diseases and conditions, from mild infections to breast cancer. Show
Pongsak Tawansaeng / EyeEm / Getty Images This symptom can be worrisome, especially if you're not certain what is causing it. The axillary lymphadenopathy differential diagnosis also may be difficult because of all the possible causes. This article will discuss possible causes and symptoms to look out for. It will help you to know when to see a healthcare provider and to understand more about diagnostic tests and axillary lymphadenopathy treatment. Symptoms of Axillary LymphadenopathyAxillary lymphadenopathy is characterized by swelling and inflammation of one or more of the 20 to 40 axillary lymph nodes in each armpit. The swelling may involve one armpit, which is known as unilateral, or both armpits, known as bilateral. Unilateral swelling is often (but not always) a symptom of an infection or disease on that side of the body. Bilateral swelling tends to point to systemic illness—that is, an illness affecting the entire body. Swollen axillary lymph nodes can range in size from a small pea to a large grape. They can feel spongy or hard like a marble. They may also be accompanied by additional symptoms, including:
Causes of Swollen Lymph Nodes in the ArmpitLymph nodes are part of the lymphatic system, which plays a central role in immune function, fluid balance, and absorption of fats and fat-soluble nutrients. Other parts of the lymphatic system include lymph fluid, lymph vessels, the spleen, tonsils, and the thymus gland. Lymphadenopathy is a sign that the lymphatic system has triggered an immune response to defend against an invader—specifically, an infection or illness. The immune response works like this:
Axillary lymphadenopathy may occur by itself or at the same time as lymphadenopathy of the neck or chest. Generalized lymphadenopathy describes the occurrence of lymphadenopathy throughout the body due to systemic illness. There are many possible causes of axillary lymphadenopathy, including:
Lung, thyroid, stomach, colorectal, pancreatic, ovarian, kidney, and skin cancer can also sometimes metastasize (spread) to the armpit area. DiagnosisAxillary lymphadenopathy can usually be identified with a physical exam. Your healthcare provider may discover swollen lymph nodes during a routine checkup even if you have no symptoms. To begin to determine if armpit pain or other symptoms could be related to cancer, infection, or another cause, they will consider several factors, including:
Together, these clues may point to certain diagnoses and help exclude others.
Healthcare providers tend to worry about lymph nodes if they develop for no apparent reason. In such cases, additional tests may be ordered to help narrow down the causes. Lab Tests and ProceduresIn addition to a physical exam, your healthcare provider will review your medical history and symptoms. They'll ask about recent vaccinations, unexplained weight loss, recent sexual exposures, or abnormal skin lesions. This information will help them determine which tests to include in the workup, such as:
Differential DiagnosisLumps and masses in the armpit don't always indicate lymphadenopathy. Some may be benign or malignant growths not related to the lymphatic system, such as:
These conditions usually can be differentiated with imaging studies and other procedures, such as fine-needle aspiration. Axillary Lymphadenopathy TreatmentThere is no specific axillary lymphadenopathy treatment. Instead, it is resolved by treating the underlying condition. Symptoms of lymphadenopathy can respond to certain home or over-the-counter (OTC) remedies:
In cases of advanced breast cancer, the axillary lymph nodes are removed as part of a radical or modified mastectomy. Lymphadenopathy caused by infection or other inflammatory processes is called lymphadenitis. To prevent the spread of lymphadenopathy to other lymph nodes in your body, your healthcare provider may prescribe antibiotics, antiviral, or anti-fungal medication. SummaryWhen your body detects a foreign invader—be it an illness, an infection, or even a vaccine—your lymphatic system will trigger an immune response to fend off the perceived threat. As lymphocytes and cytokines attack the invader, your lymph nodes will swell, resulting in lymphadenopathy. Sometimes, axillary lymphadenopathy can be a sign of a serious illness, such as HIV, lymphoma, or breast cancer. You should make an appointment with your healthcare provider if you are concerned, or if:
A Word From VerywellA swollen lymph node is not an uncommon condition. But it should never be ignored if it is persistent, severe, or unexplained. When seeing a healthcare provider, provide as much information as possible about what you had been doing or experiencing before the lymphadenopathy started. The more your healthcare provider knows, the sooner a diagnosis can be made. Frequently Asked Questions
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By Indranil Mallick, MD Thanks for your feedback! Which type of lymph nodes are located in the armpit?The lymph nodes in the armpit are called axillary lymph nodes.
What causes swollen lymph nodes in underarm?Swollen lymph nodes in the armpit can be a sign of common viral infections, such as the flu or mono. They can also occur as a result of a bacterial infection or RA. In some cases, swollen lymph nodes are a symptom of cancer. Warm compresses and OTC pain medication can ease any pain or tenderness.
When should I be concerned about axillary lymph nodes?See your doctor if you're concerned or if your swollen lymph nodes: Have appeared for no apparent reason. Continue to enlarge or have been present for two to four weeks. Feel hard or rubbery, or don't move when you push on them.
What are the 4 major axillary lymph nodes?There are five axillary lymph node groups, namely the lateral (humeral), anterior (pectoral), posterior (subscapular), central and apical nodes.
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