Long term side effects of proton therapy for prostate cancer

6.12.2021

The Proton Therapy Center Czech oncology team have published their 5 year results using a shortened schedule (‘ultrahypofractionated’) proton therapy to treat low- and intermediate-risk prostate cancer. The results, published in the International Journal of Radiation Oncology – Biology – Physics (IJROBP), has demonstrated a high 5-year disease-free survival of 96.9% for low-risk prostate cancer patients treated with proton therapy, with low-to-no side effects.

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Between January 2013 and March 2016, 284 patients with prostate cancer were treated using intensity modulated proton therapy (IMPT), with an ultrahypofractionated schedule. Data for 279 patients were prospectively collected and analysed – 43.4% of patients had low-risk, 44.8% had favourable-risk intermediate cancer, and 11.8% unfavourable-risk intermediate-risk cancer. 17.6% of patients underwent neoadjuvant hormonal therapy. Disease-free survival and and late side-effect profiles were analysed.

The results of this study showed a 5-year disease-free survival rate of 96.9% of low-risk prostate cancer patients. Additionally, for the favourable intermediate-risk prostate cancer patients analysed, 91.7% were shown to be disease-free. For unfavourable intermediate-risk prostate cancer patients, 83.5% were disease-free.

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With respect to side effects, no patients experienced any grade 4 long-term side effects as a result of treatment. 1 patient (0.36%) experienced grade 3 side effects, which have since resolved. The vast majority of patients treated experienced low-to-no long-term serious side effects as a result of treatment, leading the researchers to conclude ultrahypofractionated proton beam radiation therapy for prostate cancer is effective with long-term disease-free survival rates comparable with other fractionation schedules and with minimal serious long-term GI and GU toxicity.

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To find out if proton therapy is an appropriate treatment for you or a loved one, please contact Proton Therapy UK, the official British division of the Proton Therapy Center in Prague.

Prostate Cancer & Proton Therapy

• Proton Therapy for Prostate Cancer
• Diagnosis and Staging
• The Advantages of Proton Therapy for Prostate Cancer
• What to Expect with Proton Therapy
• Patient Stories
• Contact Us
• Other Tumors Treated

Proton Therapy for Prostate Cancer

When you’ve been diagnosed with prostate cancer, your first instinct may be to get the cancer out as quickly as possible. However, many treatments for prostate cancer can cause long-term side effects and proton therapy may be able to reduce those risks. When patients come for a consultation, our team discusses all treatments for prostate cancer, including surgery, other forms of radiation therapy, hormonal therapy and active surveillance.

Prostate cancer forms in the prostate, the muscular, walnut-sized gland that's located below the bladder and in front of the rectum. The precision of proton therapy can target the tumor and reduce damage to the surrounding tissue, which in turn may reduce side effects such as urinary complications and impotence.

Northwestern Medicine Proton Center is one of the few proton therapy centers throughout the Midwest and the only one in Illinois. Our team is dedicated to explaining all of your treatment options for prostate cancer and facilitating a conversation with you and your physician or oncologist to determine the best treatment option for you.

To learn if you can benefit from proton therapy, call 1.877.887.5807 or fill out our online form.

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Diagnosis and Staging

After a prostate cancer diagnosis, the next steps are to determine the cancer stage and decide on a treatment option. Prostate cancer diagnoses are categorized into low, intermediate, and high-risk. Your doctor will determine the category based on several tests, including a biopsy.

Stage I (Low-risk)

• Tumor is confined to one side of the prostate
• PSA score is less than 10
• Gleason score is 6 or less

Stage IIA (Intermediate-risk)

• Tumor fills half of the prostate on examination
• OR PSA score is between 10-20
• OR Gleason score is 7

Stage IIB (High-risk)

• Tumor is on both sides of prostate
• OR PSA score is over 20
• OR Gleason score is between 8-10

Stage III

• Tumor extends out of the prostate

Stage IV

• Lymph nodes are impacted by tumor

After your doctor has determined the stage of your prostate cancer, he or she will then help you decide on an appropriate form of treatment.

The Advantages of Proton Therapy for Prostate Cancer

When treating cancer with radiation, it’s important to balance the treatment of the tumor and the preservation of healthy tissue. Proton therapy allows this delicate balance to be achieved through precise targeting that conforms to the shape of the tumor, making it an excellent treatment for prostate cancer.1,3,4 With protons, a higher dose can be delivered to the tumor site, which can result in better tumor control, while largely sparing the bladder and rectum from radiation damage.1,3,4

What to Expect With Proton Therapy

Proton therapy is considered safe, non-invasive and painless. Depending on the patient's diagnosis, treatments are usually given five days a week for up to nine weeks. The time spent actually delivering the protons to the tumor is about one minute, but a prostate cancer treatment session can range from 15 to 30 minutes due to time spent positioning the patient for this precise treatment.

Patients continue with normal activities before and after treatment. Some patients choose to work; others go on a “radiation vacation” and spend their days doing recreational activities before or after treatment.

Learn more about what to expect when getting treated.

Patient Stories

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