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Vitamins are considered essential nutrients because either your body cannot make them or they are made in inadequate amounts to prevent negative health consequences or diseases.Source: Bigstock Things to know about vitamin D deficiency?The "sunshine" vitamin is a hot topic. You may have recently found out that you are deficient or know someone who is. It's shocking for most people when they have never had a problem before and believe nothing has changed to make it a problem now. The truth is that a lot has changed, and vitamin D deficiency and insufficiency are now a global public health problem affecting an estimated 1 billion people worldwide. Vitamins are considered essential nutrients because either your body cannot make them or they are made in inadequate amounts to prevent negative health consequences or diseases. So it's essential that you provide vitamins for your body by food and/or supplements. Vitamin D was discovered to be essential when it was found to be needed for the treatment of rickets. Vitamin D is one of the four fat-soluble vitamins (A, D, E, and K). There are two forms of vitamin D: D2 and D3. Vitamin D2, also known as ergocalciferol, comes from fortified foods, plant foods, and over-the-counter supplements. Vitamin D3, also known as cholecalciferol, comes from fortified foods, animal foods (fatty fish, cod liver oil, eggs, and liver), supplements, and can be made internally when your skin is exposed ultraviolet (UV) radiation from the sun. Structurally, these two are not the same. Many believe that vitamin D should be classified as a hormone, with some calling it the forgotten neurosteroid. The health consequences of being deficient go far beyond rickets and what occurs with any other vitamin. And unlike other vitamins, it can be made by your body when exposed to the sun and the active form in your body, called calcitriol, has similarities to other hormones (estrogen, cortisol, and testosterone). The real dangers of excessive exposure to the sun and skin cancer have been greatly publicized and resulted in people covering up and using sunscreen when in the sun. We have also had a shift in spending less time outdoors because of increased work hours and more sedentary lives. As a result, vitamin D levels began dropping without most health care professionals realizing it. Researchers have been focusing on the consequences of vitamin D deficiency and have found an alarming number of health issues outside of its role with rickets. These include skeletal diseases like osteoporosis, certain cancers, cardiovascular disease, autoimmune diseases, infections, inflammatory bowel diseases, psychological disorders, cognitive disorders, obesity, and or mortality. Correcting vitamin D deficiency is not as simple as taking a pill or getting more sun. This article will teach you all that you need to know about the benefits of achieving and maintaining optimal vitamin D levels and how you can do it. Symptoms of Vitamin D DeficiencyDoes vitamin D deficiency cause symptoms?Yes, deficiency of vitamin D can cause bone pain and muscle weakness. However, mild vitamin D deficiency is not necessarily associated with any symptoms. Vitamin D has been referred to as the "sunlight vitamin" because it is made in our skin when we are exposed to sunlight. The RDA is the average daily intake sufficient to meet the nutrient requirements of nearly all (97.5%) healthy individuals. See the vitamin D recommended daily allowances chart.Source: Bigstock What are the vitamin D recommended daily allowances?Only 20% of our vitamin D is meant to come from our diet with the remaining 80% provided by our skin from UV-B exposure to the sun. There are currently two sets of guidelines for vitamin D intake. Typically, vitamin guidelines are established by the Institute of Medicine (IOM) in the form of Recommended Dietary Allowances (RDA) or adequate intakes (AI). The RDA is the average daily intake sufficient to meet the nutrient requirements of nearly all (97.5%) healthy individuals. These guidelines were set on a population model to prevent vitamin D deficiency based on bone health (osteomalacia, rickets, bone mineral density, and calcium absorption) for the general population. The Endocrine Society put together a task force to review the research and came up with a set of guidelines based on a medical model for those at risk for a deficiency. The two recommendations are as follows: Vitamin D Recommended Daily Allowances Chart
These amounts are based on what is needed to maintain the blood levels that each guideline committee has established as ideal. The higher the blood level that you need to maintain, the more vitamin D you will need to maintain that level. If your blood level is deficient, these are not the guidelines for you to follow. You will first need to get your levels up by taking vitamin D above these amounts and then you will follow these levels once you have reached your adequate level. Your health care provider can provide recommendations for a safe way to do this. Many other health benefits of vitamin D and risks associated with deficiency have been reported include autoimmune disease.Source: Wikipedia – Bruce Blaus What are health risks of vitamin D deficiency?
By the turn of the 20th century, 90% of the children living in New York, Boston, and Leyden in the Netherlands were afflicted with rickets, a bone deforming disease. The first observation of this disease was in the mid-1600s by Whistler and Glissen, who reported that children living in industrialized cities in Great Britain had short stature and deformities of the skeleton, especially of the lower legs. It wasn't until 1889 that the discovery that "sunbathing" was important for preventing rickets came about. Since then, many other health benefits of vitamin D and risks associated with deficiency have been reported. These include the following: Autoimmune disease
Cancer
Cognitive disordersIt's been shown that vitamin D plays a crucial role in brain development, brain function regulation, and a healthy nervous system. Vitamin D deficiency has been found to be common in patients with Parkinson's disease, Alzheimer's disease, schizophrenia, depression, anxiety disorders, dementia, and older adults with cognitive decline. A meta-analysis reported a 2.4-times greater risk of cognitive impairment in people with low vitamin D levels versus those with adequate levels. It's been suggested that maintaining adequate levels of vitamin D levels throughout life may help to prevent age-related neurological disorders. A summit with the leading experts, including physicians and scientists, from across the world convened in 2013 to review the research in this area and to come up with clear guidelines for the medical and scientific communities. There was a unanimous agreement that low vitamin D levels and/or the insufficient utilization of vitamin D can be considered a risk factor for cognitive decline and dementia in general and supplementation was needed to correct these levels. A review of vitamin D levels in 170 women, 65-77 years of age, over 10 years found that adequate vitamin D levels may be protective against declines in cognitive flexibility and psychomotor speed components of executive function. The association between lack of sunlight and depressive disorders was first noted 2,000 years ago. There are numerous studies showing low levels of vitamin D are associated with major depression and the symptoms of depression. In a study of over 6,000 people over the age of 50, those with lower vitamin D levels reported more depressive symptoms (for example, felt sad, felt lonely, couldn't get going). Those with the lowest vitamin D levels reported the greatest degree of depressive symptoms. Only small-scale studies have shown success in improving these symptoms by correcting the deficiency. Much more research is needed in this area to find out how best to treat it. Cardiovascular disease (heart disease)
Infections
Inflammation reduction
Inflammatory bowel disease (IBD)
Obesity
Skeletal disease
Type 2 diabetes risk reduction
Adequate vitamin D levels have also been linked with improvements in kidney function, erectile dysfunction, sleep apnea, diabetic retinopathy, and decreased manic episodes in bipolar patients. There is ongoing research to determine links with vitamin D deficiency and the increase in the prevalence of asthma and allergies, autism, preterm birth, gestational diabetes, and preeclampsia. Many other health benefits of vitamin D and risks associated with deficiency have been reported include cancer.Source: iStock What are vitamin D deficiency symptoms and signs?In order to work in your body, vitamin D must bind to a protein called a receptor. Every cell in your body has receptors for vitamin D. It plays a role in your muscle, immune, and nervous systems. Symptoms of vitamin D deficiency include:
SLIDESHOWVitamin D Deficiency: How Much Vitamin D Is Enough? See SlideshowA chart displays the daily supplement intake tolerable upper limits for vitamin
D.Source: Getty Images/iStockphoto What are symptoms and signs of an excessive vitamin D intake (Daily Limits Chart)?There have never been warnings about getting too much vitamin D from the sun so many do not realize that there is such a thing as too much vitamin D. There are negative health consequences from too much vitamin D, but this can only happen with excessive doses of supplements. A Tolerable Upper Limit (UL) has been set to avoid any issues, but there is some controversy about how much is too much. A blood level above 150 ng/mL appears to be the point at which problems occur, but some suggest that levels above 120 ng/mL should be the cap. Potential problems are hypercalcemia (elevated calcium in the blood, causing weakness, confusion, constipation, loss of appetite, and painful calcium deposits), hypercalciuria (excess calcium in the urine), and hyperphosphatemia (elevated phosphate levels in the blood). Over the long term, elevated blood levels of calcium can lead to vascular and tissue calcification, with subsequent damage to the heart, blood vessels, and kidneys. Research has shown that very high doses of vitamin D can increase the risk of falls and fractures. A study of 2,256 community-dwelling women, aged 70 years or older, found that over five years those given very high doses of vitamin D experienced 15% more falls and 26% more fractures than those in the placebo group. The current UL set for vitamin D supplements is as follows: The Current UL Guideline for Vitamin D Daily Allowances by Ages Chart
The arguments against these upper limit levels stem from the fact that you can get 10,000-25,000 IU from exposure to the sun in one day. The IOM states that excessive sun exposure does not result in vitamin D toxicity because the sustained heat on the skin is thought to photodegrade vitamin D3 as it is being formed. Studies have shown that long-term supplementation of over 10,000 IU/day can cause kidney and tissue damage, but this would only occur over a long period of time. One study reports that you would need to consume 50,000 IU/day over several months to reach toxicity blood levels. A recent study found that high-dose vitamin D supplementation (20,000-40,000 IU/week) caused a slight but significant increase in hemoglobin A1C and C-reactive protein, and a decrease in serum HDL ("good" cholesterol). The best way to avoid any issues is to take appropriate levels to correct a deficiency or insufficiency and have your blood checked after a few months and then decrease to maintenance levels once you have reached the correct level. There is no disputing the fact that vitamin D plays many crucial roles in our well-being, and many of us have either deficient or inefficient blood levels. An affordable, convenient way to test vitamin D levels, similar to finger sticks used for blood sugar testing, can play a vital role in correcting low blood levels. Changes to our lifestyle, diet, and regular supplementation are the keys to curbing the vitamin D deficiency pandemic. Health NewsMany other health benefits of vitamin D and risks associated with deficiency have been reported include infections, inflammation reduction, IBD, obesity, skeletal disease, and type 2 diabetes risk reduction.Source: iStock Who is at risk for vitamin D deficiency?Being that the sun is the primary source of vitamin D, your exposure, or lack of it, will impact your risk for a deficiency. The Endocrine Society recommends screening and treatment for individuals at risk, including older adults with a history of falls or nontraumatic fractures; obese children and adults (BMI > 30 kg/m2); African-American and Hispanic children and adults; pregnant and lactating women; and people with musculoskeletal diseases, chronic kidney disease, hepatic failure, malabsorption syndromes, and some lymphomas. Ongoing monitoring is recommended for the elderly, people with disabilities, and hospitalized people as they have been shown to have a significantly higher risk. Research has begun to focus on who is deficient or insufficient in their vitamin D levels. Finding a deficiency does not mean that vitamin D is the cause of any ongoing symptoms. It simply means that there is a possible relationship, and more studies need to be done to clarify the relationship between vitamin D insufficiency or deficiency and disease processes. MalabsorptionPeople with one of the fat malabsorption syndromes (for example, Crohn's disease or celiac disease) and people who have had bariatric surgery are often unable to absorb enough of the fat-soluble vitamin D. AgeElderly: It has been shown that as we age our body has a decreased ability to synthesize vitamin D from exposure to the sun. There can be as much as 25% reduced production over the age of 70. While this can have an impact, it doesn't cause as much of a deficiency as the other risk factors. Children: A study done in Ethiopia found that schoolchildren between the ages of 11-18 years were more likely to be overweight or obese when they were deficient in vitamin D. Another study of 301 students aged 11-19 years found that 12% of the students were deficient, and 53% had insufficiency. It also found that as body weight increased (measured by BMI) the level of vitamin D decreased. Medications and medical conditionsA wide variety of medications, including antifungal medications, anticonvulsants, glucocorticoids, and medications to treat AIDS/HIV, can enhance the breakdown of vitamin D and lead to low levels. QUESTIONNext to red peppers, you can get the most vitamin C from ________________. See AnswerA woman looks at the sun through a window.Source: iStock Vitamin D deficiency causes: Darker skin, Weight
A deficiency in vitamin D can result from inadequate exposure to sunlight, inefficient production in the skin, not enough vitamin D in your diet, and health conditions that can affect it including, gastrointestinal disorders, renal diseases, and liver diseases. Darker skinMelanin is what gives skin its color. Light-skinned people have less melanin than those with darker skin. Melanin is able to absorb UV-B radiation from the sun and reduce the skin's capacity to produce vitamin D3 by 95%-99%. Dark-skinned individuals have natural sun protection and require at least three to five times longer exposures to make the same amount of vitamin D as a person with a white skin tone. African-Americans have a population mean serum 25(OH)D level of 16 ng/mL, whereas white Americans have a level of 26 ng/mL. WeightBeing overweight or obese may put you at risk for a vitamin D deficiency. A recent review of 23 studies showed that obese subjects had 35% higher rates of vitamin D deficiency compared with normal-weight subjects and 24% higher rates compared with overweight subjects. While diet and decreased sun exposure may have some impact on this, there appears to be an increased need that cannot be met without a supplement. One study tested the blood levels of vitamin D after sun exposure in both obese and non-obese subjects. Both saw an initial rise in vitamin D levels after similar exposures, but 24 hours later, there was 57% less vitamin D in the blood of the obese subjects. Both groups had a similar capacity of the skin to produce the vitamin. The difference was seen in the release of vitamin D from the skin into circulation. Subscribe to MedicineNet's Weight Loss/Healthy Living NewsletterBy clicking "Submit," I agree to the MedicineNet Terms and Conditions and Privacy Policy. I also agree to receive emails from MedicineNet and I understand that I may opt out of MedicineNet subscriptions at any time. Limited exposure to the sun can cause a vitamin D deficiency.Source: Wikipedia – Bruce Blaus Vitamin D deficiency causes: Limited exposure to the sunLimited exposure to the sunYou may look out your window and see the sun shining and think that you are safe from this deficiency, but that is not always the case. Even in sunny climates, there is an increased prevalence of vitamin D deficiency. We have all heard about the dangers of skin cancer and the need for sunscreen to protect us from this disease. This knowledge and the preventive actions we take have significantly decreased our vitamin D levels. Sunscreen protects so well against UV-B rays that an SPF of 30 decreases vitamin D synthesis in the skin by more than 95%. On top of this, we tend to spend more time indoors. One study found that it took Caucasian's exposure of more than 30% of their body every day in the summer to make the optimal amounts of vitamin D. Most adults work indoors and wear more clothing during the workweek, which leaves only about 10%-15% of their body exposed to UV for short periods, so they cannot meet their vitamin D needs through the sun alone. Even if you do have some exposure to the sun, the total amount of vitamin D you can produce is affected by the season, time of day, ozone amount, latitude, and the number of clouds in the sky. The important thing about using the sun for vitamin D production is to know that less is more. You are better off with short regular exposures to the sun rather than prolonged exposure for many reasons. The process is not as simple as the sun hitting your skin and vitamin D appearing in your blood. What happens is that vitamin D3 is first transformed by a process known as hydroxylation in the liver to 25-hydroxyvitamin D3, often written as (25(OH)D3), and then again in the kidney to its active form, 1,25-dihydroxyvitamin D3, written as (1,25(OH)2D3). The level that is checked in your blood is 25-hydroxyvitamin D, often written as 25(OH)D, which includes vitamin D2 and D3. By staying in the sun, you limit this process and can get less vitamin D. You also have a lower risk of burning and damaging your skin with short exposures. The National Cancer Council in Australia recently published a position paper on ways to minimize the risk of skin cancer while maintaining adequate vitamin D levels via exposure to the sun. Currently, one-third of the population there is deficient. Extended and deliberate sun exposure without any form of protection when the UV index is 3 or above is not recommended for anyone. When the UV index is below 3, sun protection is not recommended, and it is recommended that people be outdoors in the middle of the day with some skin uncovered on most days of the week. There are two blood tests for vitamin D. One is for a compound called 1,25(OH)2D and the 25-hydroxyvitamin D, written as 25(OH)D test. See the detailed test result chart.Source: Thinkstock Images How do health care professionals diagnose a vitamin D deficiency?
All it takes is a simple blood test to find out if you are deficient in vitamin D, but you need to have the correct test done at the correct time of year. There are two blood tests for vitamin D. One is for a compound called 1,25(OH)2D. This is one that is not a good measure for your current vitamin D level. It has a short half-life and can be impacted by your parathyroid hormone (PTH), calcium, and phosphorus levels, so it's not a true measure of your vitamin D status. The preferred test is the 25-hydroxyvitamin D, written as 25(OH)D. This is the most accurate measure of your current vitamin D status as it reflects what you get from your diet, supplements, and the sun. It is also the one that the majority of the research studies measure. As with the guidelines for how much to consume, there are also two sets of guidelines for what your blood level should be. One is written by the Institute of Medicine (IOM) and the other by the task force for the Endocrine Society. These levels are for serum (blood) 25(OH)D: IOM and Endocrine Society Guidelines for What Your Blood Level Should Be Chart
The largest meta-analysis ever conducted on all of the published studies between 1966 and 2013 regarding 25(OH)D levels and all-cause mortality found that the lowest mortality (death) risk is seen when the levels are >40 ng/mL. According to this, the IOM guidelines are too low and there is a plea calling on the public health authorities to change the recommendations for both the ideal blood level and the requirements needed to achieve this level. Your 25(OH)D level will change by season if you vary how much time you spend in the sun each season. Keep this in mind when scheduling your test. FromA man shops for vitamin D supplements.Source: Veer What is the treatment for a vitamin D deficiency?
The amount of vitamin D that is needed to correct a deficiency will depend on the severity of the deficiency and your individual medical conditions. The time of year will also impact your needs. For example, if you are on the low end of adequate blood levels and heading into the winter months you would need a bit more than if you were heading into the summer months if you spend time out in the sun. The goal for everyone is to get your stores to a safe level and prevent them from dropping with a maintenance plan. Vitamin D3 is the best choice for supplements. Vitamin D2 supplements do not raise your levels the same amount as D3 and, in some cases, they have been shown to decrease levels over long-term use. Natural sources of vitamin D2 are scarce, and the majority of research has been done using D3 supplements. What you take is as important as how you take it. Vitamin D supplements should be taken with a meal that contains fat. Studies have shown that when taken on an empty stomach versus with a meal containing fat, there was an average of 32% more vitamin D absorption in the fat-containing meal. This ranged from 11%-52%. Even an 11% reduction is significant and can impact your vitamin level. A recent study instructed people to take their supplement with their largest meal (typically the one with the most fat), and in three months, their blood levels went up an average of 56.7%. Some supplements can be taken on a daily, weekly, or monthly basis. It's a matter of preference and, most importantly, which one you will be more likely to take. When you are deficient, it is recommended to have your blood tested after two to three months of taking the supplement to be sure that your levels are going up. Work with your doctors to find the optimal plan for you. The task force for the Endocrine Society makes the following recommendations:
Foods that contain vitamin D: Raw salmon filet, a glass of milk, fresh shiitake mushrooms, and canned tuna.Source: Wikipedia – Bruce Blaus Is it possible to prevent vitamin D deficiency?A few foods naturally contain vitamin D, and other foods are fortified with it. With only 20% of our vitamin D intake expected from food, exposure to the sun and taking supplements remain the primary sources. Follow your health care provider's recommendations for supplementing on a regular basis, get some sun exposure, consume foods that contain vitamin D, have regular blood work to monitor your level, and make adjustments to your intake based on your medical needs and seasonal changes.
Medically Reviewed on 3/10/2022 References Ali, A., et al. "Developmental Vitamin D Deficiency and Autism: Putative Pathogenic Mechanisms." J Steroid Biochem Mol Biol 175 Jan. 2018: 108-118. Allan, G.M., et al. "Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs." J Gen Intern Med Mar. 7, 2016. American Academy of Orthopaedic Surgeons. "Vitamin D for Good Bone Health." OrthoInfo. Nov. 2016. <https://orthoinfo.aaos.org/en/staying-healthy/vitamin-d-for-good-bone-health/>. Anglin, R.E. "Vitamin D Deficiency and Depression in Adults: Systematic Review and Meta-analysis." Br J Psychiatry 202 Feb. 2013: 100-7. Annweiler, C. "Vitamin D in Dementia Prevention." Ann N Y Acad Sci 1367.1 Mar. 2016: 57-63. Annweiler, C., et al. "'Vitamin D and Cognition in Older Adults': Updated International Recommendations." J Intern Med 277.1 Jan. 2015: 45-57. Banihashemi, Mahnaz, et al. "Serum Vitamin D3 Level in Patients With Female Pattern Hair Loss." Int J Trichology 8.3 July-Sept. 2016: 116-120. Bičíková M, et al. "Vitamin D in Anxiety and Affective Disorders." Physiol Res 2015;64 Suppl 2:S101-3. Bischoff-Ferrari, H.A., et al. "Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial." JAMA Intern Med 176.2 Feb. 2016: 175-183. Bouillon, R., et al. "Optimal Vitamin D Status: A Critical Analysis on the Basis of Evidence-Based Medicine." J Clin Endocrinol Metab 98.8 Aug. 2013: E1283-304. Dawson-Hughes, Bess, et al. "Dietary Fat Increases Vitamin D-3 Absorption." Journal of the Academy of Nutrition and Dietetics 115.2 February 2015: 225-230. de Oliveira, C., et al. "Associations Between Vitamin D Levels and Depressive Symptoms in Later Life: Evidence From the English Longitudinal Study of Ageing (ELSA)." J Gerontol A Biol Sci Med Sci 22 June 2017. Deda, L., et al. "Improvements in Peripheral Vascular Function With Vitamin D Treatment in Deficient Adolescents With Type 1 Diabetes." Pediatr Diabetes 23 Oct. 2017. Douros, K., et al. "Asthma and Allergy 'Epidemic' and the Role of Vitamin D Deficiency." Adv Exp Med Biol 996 (2017): 169-183. Gallagher, J.C., et al. "Vitamin D Supplementation in Young White and African American Women." J Bone Miner Res 29.1 Jan. 2014: 173-81. Garland, C.F., et al. "Meta-analysis of All-Cause Mortality According to Serum 25-Hydroxyvitamin D." Am J Public Health 104.8 Aug. 2014: e43-50. Ginde, Adit A., et al. "Demographic Differences and Trends of Vitamin D Insufficiency in the US Population, 1988-2004." Arch Intern Med 169.6 Mar. 23, 2009: 626-632. Goodwill, A.M., et al. "Vitamin D Status Is Associated With Executive Function a Decade Later: Data From the Women's Healthy Ageing Project." Maturitas 107 Jan. 2018: 56-62. Gregoriou, E., et al. "The Effects of Vitamin D Supplementation in Newly Diagnosed Type 1 Diabetes Patients: Systematic Review of Randomized Controlled Trials." Rev Diabet Stud 14(2-3) Summer-Fall 2017: 260-268. Gunta, S.S. "The Effect of Vitamin D Status on Risk Factors for Cardiovascular Disease." Nat Rev Nephrol 10 Apr. 2013. Hassanalilou, T., et al. "Role of Vitamin D Deficiency in Systemic Lupus Erythematosus Incidence and Aggravation." Auto Immun Highlights 9.1 Dec. 26, 2017. Helde-Frankling, M., and L. Björkhem-Bergman. "Vitamin D in Pain Management." Int J Mol Sci 18.10 Oct. 18, 2017. Holick MF. "Vitamin D Deficiency." N Engl J Med 357 (2007): 266-281. Hossein-Nezhad, A., and M.F. Holick. "Vitamin D for Health: A Global Perspective." Mayo Clin Proc 88.7 July 2013::720-755. Hujoel, P.P. "Vitamin D and Dental Caries in Controlled Clinical Trials: Systematic Review and Meta-Analysis." Nutr Rev 71.2 Feb. 2013: 88-97. Institute of Medicine of the National Academies. "Dietary Reference Intakes for Calcium and Vitamin D." Nov. 30, 2010. .Jat, K.R. "Vitamin D Deficiency and Lower Respiratory Tract Infections in Children: A Systematic Review and Meta-Analysis of Observational Studies." Trop Doct 47.1 Jan. 2017: 77-84. Jesus, C.A., et al. "The Role of Vitamin D in Pathophysiology and Treatment of Fibromyalgia." Curr Pain Headache Rep 17.8 Aug. 2013: 355. Jorde, R. "Supplementation With High Doses of Vitamin D to Subjects Without Vitamin D Deficiency May Have Negative Effects: Pooled Data From Four Intervention Trials in Tromsø." ISRN Endocrinol 348705 Mar. 2013. Lapid, M.I. "Vitamin D and Depression in Geriatric Primary Care Patients." Clin Interv Aging 8 May 2013: 509-14. Lappe, J., P. Watson, D. Travers-Gustafson, et al. "Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial." JAMA 317.12 Mar. 28, 2017: 1234-1243. Laslett, L.L. "Moderate Vitamin D Deficiency Is Associated With Changes in Knee and Hip Pain in Older Adults: A 5-Year Longitudinal Study." Ann Rheum Dis Apr. 2013. Lee, Y.H., and S.C. Bae. "Vitamin D Level in Rheumatoid Arthritis and Its Correlation With the Disease Activity: A Meta-Analysis." Clin Exp Rheumatol 34.5 Sept.-Oct. 2016: 827-833. Lee, Y.H., and S.C. Bae. "Vitamin D Level in Rheumatoid Arthritis and Its Correlation With the Disease Activity: A Meta-Analysis." Clin Exp Rheumatol Apr. 6, 2016. Liu, Y., et al. "Vitamin D: Preventive and Therapeutic Potential in Parkinson's Disease." Curr Drug Metab 14.9 Nov. 2013: 989-93. Maddock, J., et al. "Vitamin D and Common Mental Disorders in Mid-life: Cross-sectional and Prospective Findings." Clin Nutr 32.5 Oct. 2013: 758-764. McCarty, D.E. "Nonspecific Pain Is a Marker for Hypovitaminosis D in Patients Undergoing Evaluation for Sleep Disorders: A Pilot Study." Nat Sci Sleep 5 Mar. 2013: 37-42. Mahto, H., et al. "Association Between Vitamin D Receptor Polymorphisms and Systemic Lupus Erythematosus in an Indian Cohort." Int J Rheum Dis 12 Dec. 2017. Maji, Debasish. "Vitamin D Toxicity." Indian J Endocrinol Metab 16.2 Mar.-Apr. 2012: 295-296. Marwaha, R.K., et al. "Role of Parathyroid Hormone in Determination of Fat Mass in Patients with Vitamin D Deficiency." Indian J Endocrinol Metab 21.6 Nov.-Dec. 2017: 848-853. Nsengiyumva, V., et al. "The Association of Circulating 25-Hydroxyvitamin D Concentration With Peripheral Arterial Disease: A Meta-Analysis of Observational Studies." Atherosclerosis 243.2 Dec. 2015: 645-651. O'Sullivan, M. "Vitamin D as a Novel Therapy in Inflammatory Bowel Disease: New Hope or False Dawn?" Proc Nutr Soc 74.1 Feb. 2015: 5-12. Papadimitriou, D.T. "The Big Vitamin D Mistake." J Prev Med Public Health 50.4 July 2017: 278-281. Pereira-Santos, M., et al. "Obesity and Vitamin D Deficiency: A Systematic Review and Meta-Analysis." Obes Rev 16.4 Apr. 2015: 341-349. Peterson, L.A., et al. "Vitamin D Status and Supplementation Before and After Bariatric Surgery: A Comprehensive Literature Review." Surg Obes Relat Dis Jan. 6, 2016. Qin, L.L., et al. "Does Maternal Vitamin D Deficiency Increase the Risk of Preterm Birth: A Meta-Analysis of Observational Studies." Nutrients 8.5 May 20, 2016. Sadeghian, M., et al. "Vitamin D Status in Relation to Crohn's Disease: Meta-Analysis of Observational Studies." Nutrition 32.5 May 2016: 505-514. Sharma, S., et al. "Does Vitamin D Supplementation Improve Glycaemic Control in Children With Type 1 Diabetes Mellitus? A Randomized Controlled Trial." J Clin Diagn Res 11.9 Sept. 2017. Sintzel, M.B., et al. "Vitamin D and Multiple Sclerosis: A Comprehensive Review." Neurol Ther 14 Dec. 2017. Spedding, S. "Vitamin D and Depression: A Systematic Review and Meta-Analysis Comparing Studies With and Without Biological Flaws." Nutrients 6.4 Apr. 11, 2014: 1501-1518. Tsuprykov, O., et al. "Why Should We Measure Free 25(OH) Vitamin D?" J Steroid Biochem Mol Biol 4 Dec. 2017. Vanlint, S. "Vitamin D and Obesity." Nutrients 5.3 Mar. 2013: 949-56. Wakayo, T., et al. "Vitamin D Deficiency Is Associated With Overweight and/or Obesity Among Schoolchildren in Central Ethiopia: A Cross-Sectional Study." Nutrients 8.4 Apr. 1, 2016. Whiting, S.J., et al. "Moderate Amounts of Vitamin D3 in Supplements are Effective in Raising Serum 25-Hydroxyvitamin D from Low Baseline Levels in Adults: A Systematic Review." Nutrients 7.4 Apr. 1, 2015: 2311-2323. Valipour, G., et al. "Serum Vitamin D Levels in Relation to Schizophrenia: A Systematic Review and Meta-Analysis of Observational Studies." J Clin Endocrinol Metab 99.10 Oct. 2014: 3863-3872. Wang, J., et al. "Meta-Analysis of the Association Between Vitamin D and Autoimmune Thyroid Disease." Nutrients 7.4 Apr. 3, 2015: 2485-2498. Wei, S.Q., et al. "Maternal Vitamin D Status and Adverse Pregnancy Outcomes: A Systematic Review and Meta-Analysis." J Matern Fetal Neonatal Med 26.9 June 2013: 889-899. Wimalawansa, S.J. "Associations of Vitamin D With Insulin Resistance, Obesity, Type 2 Diabetes, and Metabolic Syndrome." J Steroid Biochem Mol Biol Jan. 2018. Xu, M.Y., et al. "Vitamin D and Graves' Disease: A Meta-Analysis Update." Nutrients 7.5 May 21, 2015: 3813-3827. Zhang, J., et al. "Relationship Between Vitamin D Deficiency and Diabetic Retinopathy: A Meta-Analysis." Can J Ophthalmol 52 Suppl 1 Nov. 2017: S39-S44. Zhou, J., et al. "Association of Vitamin D Deficiency and Frailty: A Systematic Review and Meta-Analysis." Maturitas 94 Dec. 2016: 70-76. How long does it take to recover vitamin D levels?Generally, it takes a few weeks of taking daily vitamin D supplements for vitamin D levels in the body to rise. Each 1,000 IU of vitamin D3 taken daily is expected to raise blood levels of 25(OD)D by 10 ng/ml after a few weeks.
How can I get my vitamin D levels up quickly?Spend time in sunlight. Vitamin D is often referred to as “the sunshine vitamin” because the sun is one of the best sources of this nutrient. ... . Consume fatty fish and seafood. ... . Eat more mushrooms. ... . Include egg yolks in your diet. ... . Eat fortified foods. ... . Take a supplement. ... . Try a UV lamp.. Can you fully recover from vitamin D deficiency?The outlook (prognosis) of vitamin D deficiency is usually excellent. Both the vitamin levels and the symptoms usually respond well to treatment. However, it can take time (months) for bones to recover and for symptoms such as pain to improve. The complications of severe deficiency have been mentioned.
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