How long does it take for vascepa to lower triglycerides

  • along with certain medicines (statins) to reduce the risk of heart attack, stroke and certain types of heart issues requiring hospitalization in adults with heart (cardiovascular) disease, or diabetes and 2 or more additional risk factors for heart disease.
  • along with a low-fat and low-cholesterol diet to lower high levels of triglycerides (fats) in adults.

It is not known if VASCEPA changes your risk of having inflammation of your pancreas (pancreatitis).
It is not known if VASCEPA is safe and effective in children.

  • Heart rhythm problems (atrial fibrillation and atrial flutter). Heart rhythm problems which can be serious and cause hospitalization have happened in people who take VASCEPA, especially in people who have heart (cardiovascular) disease or diabetes with a risk factor for heart (cardiovascular) disease, or who have had heart rhythm problems in the past. Tell your doctor if you get any symptoms of heart rhythm problems such as feeling as if your heart is beating fast and irregular, lightheadedness, dizziness, shortness of breath, chest discomfort or you faint.
  • Possible allergic reactions if you are allergic to fish or shellfish. Stop taking VASCEPA and tell your doctor right away or get emergency medical help if you have any signs or symptoms of an allergic reaction.
  • Bleeding. Serious bleeding can happen in people who take VASCEPA. Your risk of bleeding may increase if you are also taking a blood thinner medicine.

If you have liver problems and are taking VASCEPA, your doctor should do blood tests during treatment.
The most common side effects of VASCEPA include:

  • Muscle and joint pain
  • Swelling of the hands, legs, or feet
  • Constipation
  • Gout
  • Heart rhythm problems (atrial fibrillation)

These are not all the possible side effects of VASCEPA. Call your doctor for medical advice about side effects. You may report adverse events (i.e. side effects) or product complaints by contacting AmarinConnect at 1-855-VASCEPA (1-855-827-2372), emailing [email protected], or calling the FDA at 1-800-FDA-1088.

Tell your doctor if you take medicines that affect your blood clotting (anticoagulants or blood thinners).

For more information on VASCEPA, click here to see the full Patient Information or call 1-855-VASCEPA (1-855-827-2372).

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Vascepa Side Effects Center

What Is Vascepa?

Vascepa (icosapent ethyl) is a type of omega-3 fatty acid, a fat found in fish oil. It is used along with a low-fat and low-cholesterol diet, to lower high triglycerides (fats). Vascepa is thought to work by decreasing the amount of triglycerides made by the body.

What Are Side Effects of Vascepa?

Common side effects of Vascepa include:

  • joint pain or sore throat

Vascepa may cause serious side effects including:

  • hives,
  • difficulty breathing, and
  • swelling of your face, lips, tongue or throat

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Vascepa

The recommended dosage is 2 capsules (4 grams) twice daily with food.

What Drugs, Substances, or Supplements Interact with Vascepa?

Vascepa may interact with other drugs affecting coagulation (e.g., anti-platelet agents). Tell your doctor all medications and supplements you take.

Vascepa During Pregnancy and Breastfeeding

If you are pregnant, only take Vascepa if the potential benefit outweighs the potential risk to the fetus. Vascepa passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Vascepa (icosapent ethyl) Side Effects Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How long does it take for vascepa to lower triglycerides

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast or irregular heartbeats, dizziness, shortness of breath, chest discomfort, fainting, or if you feel light-headed; or
  • serious bleeding.

Common side effects may include:

  • muscle or joint pain;
  • constipation;
  • swelling of the hands, legs, or feet.
  • gout; or
  • chest pressure, racing or pounding heartbeats, fluttering in your chest, feeling short of breath.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How long does it take for vascepa to lower triglycerides

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Vascepa Professional Information

SIDE EFFECTS

The following important adverse reactions are described below and elsewhere in the labeling:

  • Atrial Fibrillation or Atrial Flutter [see WARNINGS AND PRECAUTIONS]
  • Potential for Allergic Reactions in Patients with Fish Allergy [see WARNINGS AND PRECAUTIONS]
  • Bleeding [see WARNINGS AND PRECAUTIONS]

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Cardiovascular Outcomes Trial

In a double-blind, randomized, placebo-controlled cardiovascular outcomes trial, 8,179 statin-stabilized patients were randomized to receive VASCEPA or placebo and followed for a median of 4.9 years [see Clinical Studies]. The median age at baseline was 64 years, 29% were women, 90% White, 5% Asian, 2% were Black, and 4% identified as Hispanic ethnicity.

Common adverse reactions (incidence ≥3% on VASCEPA and ≥1% more frequent than placebo) included musculoskeletal pain, peripheral edema, constipation, gout, and atrial fibrillation.

Hypertriglyceridemia Trials

In two randomized, double-blind, placebo-controlled trials in patients with triglyceride levels between 200 and 2000 mg/dL treated for 12 weeks, adverse reactions reported with VASCEPA at an incidence ≥1% more frequent than placebo based on pooled data included arthralgia and oropharyngeal pain.

Postmarketing Experience

Additional adverse reactions have been identified during post-approval use of VASCEPA. Because these reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

  • Diarrhea
  • Blood triglycerides increased
  • Abdominal discomfort
  • Pain in the extremities

DRUG INTERACTIONS

Increased Bleeding Risk With Anticoagulants And Antiplatelet Agents

Some published studies with omega-3 fatty acids have demonstrated prolongation of bleeding time. The prolongation of bleeding time reported in those studies has not exceeded normal limits and did not produce clinically significant bleeding episodes. Monitor patients receiving VASCEPA and concomitant anticoagulants and/or antiplatelet agents for bleeding.

Read the entire FDA prescribing information for Vascepa (Icosapent Ethyl Capsules)

© Vascepa Patient Information is supplied by Cerner Multum, Inc. and Vascepa Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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How much will Vascepa lower triglycerides?

Compared to placebo, triglyceride levels were lowered by roughly 33% in those taking 4 grams of Vascepa daily. Additionally, VLDL was lowered by 27.9%.

When is the best time to take Vascepa?

Swallow Vascepa (icosapent ethyl) capsules whole. Don't chew, break, or open them to make sure the medication works best for you. Take Vascepa (icosapent ethyl) with or right after food. While taking Vascepa (icosapent ethyl), continue eating a healthy diet and exercise regularly.

How long should I take Vascepa?

How long can you take Vascepa? Vascepa is intended for long-term and even lifelong treatment. Clinical studies have shown that Vascepa does not make a difference in cardiovascular outcomes until two years of treatment and does not produce a substantial difference until five or six years of treatment.

Does Vascepa make you lose weight?

There are no documented reports that Vascepa helps with weight loss.

Can I take 4 Vascepa at once?

What's the recommended dosage for the Vascepa 1-gram capsule? The recommended dosage of Vascepa when you take the 1-gram (g) capsule is to take 2 capsules by mouth twice per day. Your total daily dose of Vascepa should be 4 g (4 capsules).

How much Vascepa should you take a day?

Dosage and Administration The daily dose of VASCEPA is 4 grams per day taken as either: four 0.5 gram capsules twice daily with food; or as. two 1 gram capsules twice daily with food.