A nurse is preparing to administer clozapine for the first time to a client who has schizophrenia

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Comparative Risks of Weight Gain and Extrapyramidal Symptoms With Typical and Atypical Antipsychotic Agents2

DrugWeight GainExtrapyramidal Symptoms
Typical Antipsychotics (First-Generation Antipsychotics)
Chlorpromazine (Thorazine)+++++
Fluphenazine (Prolixin)+++++
Haloperidol (Haldol)+++++
Perphenazine (Trilafon)+++++
Thioridazine (Mellaril)++++
Thiothixene (Navane)+++++
Atypical Antipsychotics (Second-Generation Antipsychotics)
Aripiprazole (Abilify)++
Asenapine (Saphris)+++
Clozapine (Clozaril)+++++
Iloperidone (Fanapt)++±
Lurasidone (Latuda)±+
Olanzapine (Zyprexa)++++++
Paliperidone (Invega)++++
Quetiapine (Seroquel)+++
Risperidone (Risperdal)++++
Ziprasidone (Geodon)+++